Evidence map›Paper›PMID 40351099›Full record

ArticleAging cell2025

Reducing HuD Levels Alleviates Alzheimer's Disease Pathology in 5xFAD Mice.

Eunbyul Ji, Apala Pal, Quia C Claybourne, Marc Michel, Rachel Munk, Ross A McDevitt, Chang-Yi Cui, Myriam Gorospe

Abstract read
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eunbyul JiLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, Maryland, USA.
Apala PalLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, Maryland, USA.
Quia C ClaybourneComparative Medicine Section, National Institute on Aging (NIA) Intramural Research Program, National Institutes of Health (NIH), Baltimore, Maryland, USA.
Marc MichelLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, Maryland, USA.
Rachel MunkLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, Maryland, USA.
Ross A McDevittComparative Medicine Section, National Institute on Aging (NIA) Intramural Research Program, National Institutes of Health (NIH), Baltimore, Maryland, USA.
Chang-Yi CuiLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, Maryland, USA.
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging (NIA) Intramural Research Program (IRP), National Institutes of Health (NIH), Baltimore, Maryland, USA.

Funding

Post-transcriptional Regulation Of Proliferative and Stress Response GenesZ01AG000511 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM NONE · 1998 to 2008
$1.6M
Intramural NIH HHS Z01 AG000511NIA IRP, NIH AG000511
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative pathology in older persons. The accumulation of amyloid β (Aβ) plaques is a major contributor to AD development. The RNA-binding protein HuD/ELAVL4 has been implicated in the formation of Aβ plaques, but its role in AD is unclear. Here, we report that ablation of HuD from CAMK2A

Indexed as

Alzheimer DiseaseELAV-Like Protein 4Amyloid beta-PeptidesAnimalsDisease Models, AnimalHumansMiceMice, TransgenicPlaque, AmyloidAmyloid beta-PeptidesELAV-Like Protein 45xFADAlzheimer's diseaseaβ plaquesElavl4homecage activityHuD

Identifiers

PMID40351099
PMCPMC12151878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.