Evidence map›Paper›PMID 40351081›Full record

ArticleCurrent stem cell research & therapy2025

Efficacy and Safety of Human Umbilical Cord Mesenchymal Stem Cells in Improving Fertility in Polycystic Ovary Syndrome Mice.

Lukuo Jin, Chenchen Ren, Li Yang, Yuanhang Zhu, Genxia Li, Yun Chang, Junxiao Du, Zhaoyuan Yang, Yuchao Yuan

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Article in Current stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lukuo JinDepartment of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Chenchen RenDepartment of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Li YangDepartment of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Yuanhang ZhuDepartment of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Genxia LiDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
Yun ChangDepartment of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Junxiao DuDepartment of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.
Zhaoyuan YangDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
Yuchao YuanDepartment of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.

Funding

National Key Laboratory of Cervical Diseases in the Third Affiliated Hospital of Zhengzhou University 144132900102021093
6 · The paper itself

Abstract

backgroundPolycystic ovary syndrome (PCOS) is the most prevalent reproductive endocrine illness in women of reproductive age and is one of the most important causes of female infertility. The pathogenesis of PCOS is complex. Although mesenchymal stem cell therapy is anticipated to be a successful treatment for PCOS, its long-term safety, including tumorigenesis in patients, remains unknown.

objectiveThis study aimed to confirm the efficacy and safety of human umbilical cord mesenchymal stem cells in improving fertility in PCOS mice.

methodsIn this study, dehydroepiandrosterone (DHEA) was used to construct a C56BL/6 mouse PCOS model, human umbilical cord mesenchymal stem cells (hUC-MSCs) were used as a treatment, and the reproductive phenotype was observed in parallel breeding experiments to confirm the efficacy of the treatment. A 4-month follow-up period, final blood tests, and organ histology were carried out to confirm the long-term safety of the treatment.

resultsAfter hUC-MSCs treatment, the sex hormone disorder of mice was corrected, the morphology and function of the ovary were improved, the number of offspring was significantly increased compared to the control group, and no adverse reactions related to stem cell transplantation such as tumor formation were found within 4 months.

conclusionThe treatment of hUC-MSCs is safe and effective in treating PCOS over the long term.

Indexed as

FertilityMesenchymal Stem CellsMesenchymal Stem Cell TransplantationPolycystic Ovary SyndromeUmbilical CordAnimalsDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLOvarycell transplantationfertilityHuman umbilical cord mesenchymal stem cellsmicepolycystic ovary syndromesafety.

Identifiers

PMID40351081

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