Evidence map›Paper›PMID 40350967›Full record

ArticleActa ophthalmologica2025

Prevalence of central serous chorioretinopathy in Denmark.

Ida N Frederiksen, Danson V Muttuvelu, Rodrigo Anguita, Lasse J Cehofski, Nathalie S Eriksen, Carsten Faber, Mads K Falk, Lorenzo Ferro Desideri, Giuseppe Giannaccare, Jakob Grauslund and 10 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta ophthalmologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ida N FrederiksenDepartment of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
Danson V MuttuveluMitØje v/ Danske Speciallæger ApS, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-4304-9704
Rodrigo AnguitaMoorfields Eye Hospital, NHS Foundation Trust, London, UK.
Lasse J CehofskiDepartment of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark.
Nathalie S EriksenDepartment of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
Carsten FaberDepartment of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
Mads K FalkFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lorenzo Ferro DesideriDepartment of Ophthalmology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-0715-6369
Giuseppe GiannaccareEye Clinic, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.ORCID https://orcid.org/0000-0003-2617-0289
Jakob GrauslundDepartment of Ophthalmology, Odense University Hospital, Odense, Denmark.ORCID https://orcid.org/0000-0001-5019-0736
Michael Stormly HansenDepartment of Ophthalmology, Rigshospitalet, Glostrup, Denmark.ORCID https://orcid.org/0000-0001-8610-7455
Josef HuemerMoorfields Eye Hospital, NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0001-5238-8295
Morten B LarsenØjenlæge Morten Bøgelund Larsen, Tønder, Denmark.ORCID https://orcid.org/0000-0001-9740-2580
Ligor P KiruparajanDepartment of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark.
Chris B SøndergaardDepartment of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark.
Andrea TaloniDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Tobias E Torp-PedersenDepartment of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
Elon H C van DijkDepartment of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Marie L R RasmussenDepartment of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
Yousif SubhiDepartment of Ophthalmology, Rigshospitalet, Glostrup, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCentral serous chorioretinopathy (CSC) is a prevalent maculopathy, but epidemiological studies are few. In this study, we determined the prevalence of CSC for the first time in a Scandinavian population.

methodsThis cross-sectional study was based on nationwide opportunistic retinal examination from 79 high street chain optician stores in Denmark. Retinal imaging was made using non-mydriatic colour fundus photography. Any abnormal result in the optometrist-facilitated retinal examination was referred to tele-ophthalmologic evaluation, which was performed by experienced consultant ophthalmologists who diagnosed CSC.

resultsDuring the 4-year study period, a total of 968 610 unique individuals underwent retinal examination, which corresponded to 16.3% of the entire population of Denmark. Of these, 113 individuals were diagnosed with CSC, which corresponded to a prevalence of 14 per 100 000. Individuals with CSC presented at a mean age of 48.2 ± 12.3 years; however, CSC was present in a large age range as both teenagers and the elderly with CSC were identified. Male biological sex was a statistically significant risk factor (odds ratio: 2.33; 95% confidence interval: 1.64-3.33, p < 0.0001). By extrapolating prevalence numbers to population statistics, we estimate that 219 females and 511 males had CSC in Denmark in December 2022.

conclusionWe identified a prevalence of 14 per 100 000, confirmed male biological sex as a significant risk factor for CSC, and found that the disease most commonly occurs among individuals aged 30-60 years. Further studies with multimodal imaging including optical coherence tomography are warranted for better accuracy.

Indexed as

Central Serous ChorioretinopathyAdolescentAdultAgedCross-Sectional StudiesDenmarkFemaleFluorescein AngiographyFundus OculiHumansMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsTomography, Optical Coherencecentral serous chorioretinopathyDenmarkepidemiologyprevalence

Identifiers

PMID40350967
PMCPMC12531604

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.