Evidence map›Paper›PMID 40350961›Full record

ArticlePhysiological reports2025

Trans-right ventricle metabolite gradients in obesity highlight multiple metabolic pathways.

Hanna M Knauss, Mythri Ambatipudi, Leah B Kosyakovsky, Matthew S Herzig, Jessica K Wang, Elizabeth E Liu, Emily S Lau, Jenna N McNeill, Xu Shi, Robert E Gerszten and 4 more

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hanna M KnaussDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Mythri AmbatipudiDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Leah B KosyakovskyDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Matthew S HerzigDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Jessica K WangDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Elizabeth E LiuDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Emily S LauDivision of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jenna N McNeillDivision of Pulmonary and Critical Care Medicine, Duke University Hospital, Durham, North Carolina, USA.
Xu ShiDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Robert E GersztenDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Naomi M HamburgWhitaker Cardiovascular Institute, School of Medicine, Boston University, Boston, Massachusetts, USA.
Gregory D LewisDivision of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jeremy M RobbinsDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Jennifer E HoDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0002-7987-4768

Funding

HFpEF Susceptibility in Women: The Role of InflammationK23HL159243 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Emily Lau · 2022 to 2026
$1.1M
American Heart Association (AHA) 853922National Institutes of Health (NIH) K23-HL150327National Institutes of Health (NIH) K23-HL159243National Institutes of Health (NIH) K24-HL153669National Institutes of Health (NIH) R01-HL134893National Institutes of Health (NIH) R01-HL160003National Institutes of Health (NIH) R01-HL168889National Institutes of Health (NIH) T32-HL160522NHLBI NIH HHS K23 HL159243
6 · The paper itself

Abstract

Obesity and metabolic dysfunction are associated with pulmonary vascular remodeling, yet molecular mechanisms remain poorly understood. We sought to study trans-right ventricular (RV) metabolite gradients to elucidate potential molecular pathways operant among individuals with obesity and pulmonary hypertension. In this study, 38 individuals with obesity (mean age 58 years, 68% women, average BMI 36.6 kg/m

Indexed as

Heart VentriclesHypertension, PulmonaryMetabolic Networks and PathwaysObesityAgedFatty AcidsFemaleHumansLipid MetabolismMaleMetabolomeMiddle AgedFatty Acidsmetabolite gradientsobesitypulmonary hypertensiontrans‐right ventricle

Identifiers

PMID40350961
PMCPMC12066817

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.