ReviewEye and vision (London, England)2025
Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies.
Review in Eye and vision (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.Ophthalmology and therapy · 2026Review
- A Continuous Severity Index for Keratoconus Diagnosis Based on Kolmogorov-Arnold Networks in a Chinese Population.Ophthalmology science · 2026Article
- Clinical Outcomes and Complications After INTACS Implantation in Keratoconus: A Systematic Review.Journal of clinical medicine · 2026Review
- Hormonal Modulation of Keratoconus: A Systematic Review and Screening Strategy for At-Risk Populations.Ophthalmology science · 2026Review
- Analysis of corneal biomechanical characteristics and clinical correlations in children with dust mite-allergic conjunctivitis.Scientific reports · 2026Article
- Interventional Keratoconus Management: The Critical Imperative for Early Detection and Treatment.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Enhancing the diagnostic precision of subclinical keratoconus by combining indices from Scheimpflug tomography, corneal biomechanics, and anterior segment optical coherence tomography.International journal of ophthalmology · 2026Article
- Investigating intraocular pressure fluctuations using corneal visualization Scheimpflug technology tonometry (CST) with varied resting intervals.Frontiers in medicine · 2026Article
- Advancing subclinical keratoconus detection using polarization-sensitive optical coherence tomography and artificial intelligence.Biophotonics discovery · 2026Article
- Influence of Scleral Contact Lenses on Optical Coherence Tomography Parameters in Keratoconus Patients.Diagnostics (Basel, Switzerland) · 2025Article
- The Effects of Eye Rubbing on Corneal Topography and Biomechanics in Children With Allergic Conjunctivitis.Translational vision science & technology · 2025Observational
- Metaheuristic-optimized swin transformer with SHAP explainability for keratoconus classification from corneal topography maps.International ophthalmology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundEarly detection of keratoconus is essential for maximizing the potential of cross-linking treatments designed to halt keratoconus progression, minimizing the risks of iatrogenic ectasia as well as reducing the need for corneal transplantation. This review focuses on the progress that has been made in the early detection of keratoconus using biomechanical and topographical properties derived from three different technologies, namely the ocular response analyser (ORA), corneal visualization Scheimpflug tonometer (Corvis ST) and optical coherence tomography (OCT).
methodA PubMed search was performed using the keywords of 'early keratoconus', 'subclinical keratoconus', 'forme fruste keratoconus', 'very asymmetric ectasia with normal topography/tomography' and 'ocular response analyser' and/or 'Corvis ST'/'corneal visualized Scheimpflug tomographer/tomography' and/or 'optical coherence tomography/tomographer'.
resultsThe integration of biomechanical parameters and corneal morphological data from the topography/tomography or OCT, or the assessment of bilateral asymmetry, has demonstrated improvement in the accuracy of diagnosing early-stage keratoconus.
conclusionsAs measurement principles differ depending on the technique used for keratoconus assessment, comprehensive metrics may be needed to reflect subtle anterior or posterior corneal changes and help identify eyes with very early ectasia. Although clinical experts have always, and will most likely, continue to play a pivotal role in decision-making for early keratoconus diagnosis, future developments in technology and AI may lead to enhanced early detection in the future.
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