Evidence map›Paper›PMID 40350155›Full record

ArticleAnesthesia and pain medicine2025

Treatment of severe pain in a patient with a cervical spinal cord injury at C5-7 level using an intrathecal targeted drug delivery system - A case report.

Yeong-Min Yoo, Ji-Eun Jung, Hyun-Jin Kim, Hyeon-Soo Park, Hye-Jin Kim, Gyeong-Jo Byeon

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesia and pain medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yeong-Min YooDepartment of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Ji-Eun JungDepartment of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Hyun-Jin KimDepartment of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Hyeon-Soo ParkDepartment of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Hye-Jin KimDepartment of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Gyeong-Jo ByeonDepartment of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.

Funding

Pusan National University Hospital
6 · The paper itself

Abstract

backgroundPatients with cervical spinal cord injury (SCI) can experience pain refractory to aggressive multimodal therapies. Here, we report the use of an intrathecal targeted drug delivery (ITDD) system to treat severe pain in patients with cervical SCI. CASE: A 64-year-old male patient underwent spinal cord stimulation (SCS) for severe cervical SCI. We proceeded with the ITDD system, placing the catheter tip at the C6 level. After placement of the ITDD system, the patient was monitored for regular refills of morphine sulfate in the drug delivery reservoir every 6 months. We reduced the oral morphine equivalent dose from nearly 333.8 mg/day to 133.8 mg/day.

conclusionsThe ITDD system may be a useful treatment option for patients with cervical SCI who have failed conventional treatments and do not show improvement with SCS.

Indexed as

Drug delivery systemsImplantationIntrathecal injectionMorphineSpinal cord injuriesSpinal cord stimulation

Identifiers

PMID40350155
PMCPMC12066199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.