Evidence map›Paper›PMID 40350095›Full record

ArticleThe Journal of allergy and clinical immunology2025

Expansion of multiple CD4

Charles F Anderson, Michelle Makiya, Knaunong Xiong, Lori Penrod, Lauren Wetzler, JeanAnne Ware, Gregory M Constantine, Paneez Khoury, Amy D Klion

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In one paragraph

Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Charles F AndersonLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: charles.anderson@nih.gov.
Michelle MakiyaLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Knaunong XiongLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Lori PenrodLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Lauren WetzlerLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
JeanAnne WareLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Gregory M ConstantineLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Paneez KhouryLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Amy D KlionLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

Funding

Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

backgroundLymphocytic variant hypereosinophilic syndrome (LHES) is a rare disorder characterized by hypereosinophilia, the presence of phenotypically aberrant populations of T

objectiveWe sought to further delineate the surface phenotypes and cytokine profiles of the aberrant lymphocyte populations in patients with LHES.

methodsMultiparameter flow cytometry was used to analyze lymphocytes in whole blood and stored peripheral blood mononuclear cells from a cohort of 42 untreated and treated patients with LHES.

resultsSurface receptor profiling of the aberrant population in 22 untreated patients with LHES, including 8 patients with episodic angioedema with eosinophilia, confirmed prior data demonstrating that the aberrant CD4

conclusionThese data provide further evidence for direct involvement of the aberrant T-cell populations in disease pathogenesis in LHES and a rationale for further exploration of T-cell-directed therapies.

Indexed as

CD4-Positive T-LymphocytesHypereosinophilic SyndromeAdultAgedCell LineageCytokinesFemaleHumansMaleMiddle AgedYoung AdultCytokineschemokine receptorEosinophilhypereosinophilic syndromelymphocytic variant hypereosinophilic syndromeregulatory T cell

Identifiers

PMID40350095
PMCPMC12353859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.