Evidence map›Paper›PMID 40350068›Full record

ArticlePhysiology & behavior2025

Associations of CO

Marissa Raskin, Nicole E Keller, Laura A Agee, Cassidy A Malone, Silvia Quevedo, Emily N Hilz, Rheall F Roquet, Jason Shumake, Jasper A J Smits, Michael J Telch and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marissa RaskinInterdisciplinary Neuroscience Program, The University of Texas at Austin, 1 University Station, Stop C7000, Austin, TX 78712.
Nicole E KellerInterdisciplinary Neuroscience Program, The University of Texas at Austin, 1 University Station, Stop C7000, Austin, TX 78712.
Laura A AgeeDepartment of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712.
Cassidy A MaloneDepartment of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712.
Silvia QuevedoDepartment of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712.
Emily N HilzDepartment of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712.
Rheall F RoquetDepartment of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712.
Jason ShumakeDepartment of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712.
Jasper A J SmitsDepartment of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712.
Michael J TelchDepartment of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712.
Michael W OttoDepartment of Psychological & Brain Sciences, Boston University, 64 Cummington Mall, Room 149, Boston, MA 02215.
Hongjoo J LeeInterdisciplinary Neuroscience Program, The University of Texas at Austin, 1 University Station, Stop C7000, Austin, TX 78712; Department of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712.
M H MonfilsInterdisciplinary Neuroscience Program, The University of Texas at Austin, 1 University Station, Stop C7000, Austin, TX 78712; Department of Psychology, University of Texas at Austin, 108 E. Dean Keeton Street, Stop A8000, Austin, TX 78712. Electronic address: marie.monfils@utexas.edu.

Funding

1/2: CO2 Reactivity as a Biomarker of Non-response to Exposure-based TherapyR01MH125951 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Marie H. Monfils, Jasper Smits · 2022 to 2026
$3.6M
2/2-CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based TherapyR01MH125949 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Michael W. Otto · 2022 to 2026
$2.8M
CO2 reactivity and orexin activation as predictors of extinction phenotype to fear and reward cuesF31AA030936 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI RASKIN, MARISSA RENEE · 2023 to 2024
$90k
NIAAA NIH HHS F31 AA030936NIMH NIH HHS R01 MH125949NIMH NIH HHS R01 MH125951
6 · The paper itself

Abstract

Pavlovian conditioning can be used to model maladaptive associations seen in anxiety/trauma and substance use disorders. One approach to attenuate conditioned responses is extinction learning (which underlies exposure therapy), wherein cues are repeatedly presented without the expected fearful or rewarding outcome. Extinction is not effective for all; therefore, identifying biomarkers that can phenotype non-responders is necessary to optimize treatment. The orexin system is involved in fear and reward extinction and responses to CO

Indexed as

Carbon DioxideCuesExtinction, PsychologicalFearMemoryOrexinsRewardAnimalsConditioning, ClassicalMaleRatsRats, Sprague-DawleyCarbon DioxideOrexinsCO(2) reactivityExtinctionFearIndividual differencesOrexinReward

Identifiers

PMID40350068
PMCPMC12280987

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.