Evidence map›Paper›PMID 40350061›Full record

ArticleThe American journal of pathology2026

The Patatin-Like Phospholipase Domain-Containing 3 148M Variant Exacerbates Alcohol-Induced Liver Injury and Tumorigenesis in Mice.

Jung-Hyo Cho, Hyeong-Geug Kim, Menghao Huang, Shen Wang, Sheng Liu, Alex Lu, Kyle McCrocklin, Yang Zhang, Zhigang Fang, Juexin Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jung-Hyo ChoDepartment of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana; Department of East and West Cancer Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon, Republic of Korea.
Hyeong-Geug KimDepartment of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana.
Menghao HuangDepartment of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana; Center for Diabetes and Metabolic Diseases, Indiana University, Indianapolis, Indiana; Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana.
Shen WangDepartment of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana.
Sheng LiuMelvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana; Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana.
Alex LuPark Tudor School, Indianapolis, Indiana.
Kyle McCrocklinLuddy School of Informatics, Computing, and Engineering, Indiana University, Indianapolis, Indiana.
Yang ZhangDepartment of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana.
Zhigang FangDepartment of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana.
Juexin WangLuddy School of Informatics, Computing, and Engineering, Indiana University, Indianapolis, Indiana; Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, Indiana.
Wanqing LiuDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan.
Jun WanMelvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana; Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana; Luddy School of Informatics, Computing, and Engineering, Indiana University, Indianapolis, Indiana; Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, Indiana.
X Charlie DongDepartment of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana; Center for Diabetes and Metabolic Diseases, Indiana University, Indianapolis, Indiana; Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana; Luddy School of Informatics, Computing, and Engineering, Indiana University, Indianapolis, Indiana; Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, Indiana. Electronic address: xcdong@iu.edu.

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injuryR01AA028506 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI X. Charlie Dong · 2022 to 2026
$2.2M
A Precision Medicine for Alcohol-Associated Liver DiseaseUT2AA031151 · NIAAA · GENETOBE INC. · PI BISGAIER, CHARLES LARRY, LIU, WANQING · 2023 to 2024
$2.0M
Epigenetic regulation in liver fibrosisR01DK121925 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE · 2020 to 2023
$1.8M
Role of ATG14 in the regulation of hepatic functionR01DK120689 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE · 2020 to 2023
$1.7M
A Precision Targeted Therapeutics for Nonalcoholic Fatty Liver DiseaseR01DK124612 · NIDDK · WAYNE STATE UNIVERSITY · PI LIU, WANQING · 2021 to 2024
$1.7M
Indiana Genomics Research Training Program for Data Scientists (INGEN4DS)R25HG012325 · NHGRI · INDIANA UNIVERSITY INDIANAPOLIS · PI Kun Huang, Yunlong Liu · 2022 to 2026
$1.3M
Role of SIRT6 in the pancreatic beta cell agingR21AG072288 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE · 2022 to 2023
$436k
NHGRI NIH HHS R25 HG012325NIAAA NIH HHS R01 AA028506NIAAA NIH HHS UT2 AA031151NIA NIH HHS R21 AG072288NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK120689NIDDK NIH HHS R01 DK121925NIDDK NIH HHS R01 DK124612
6 · The paper itself

Abstract

The patatin-like phospholipase domain-containing 3 (PNPLA3) protein 148M variant is strongly associated with cirrhosis and hepatocellular carcinoma (HCC). However, the underlying mechanisms remain elusive. This study aimed to elucidate the role of the PNPLA3

Indexed as

CarcinogenesisCarcinoma, HepatocellularLipaseLiver Diseases, AlcoholicLiver NeoplasmsMembrane ProteinsPhospholipases A2, Calcium-IndependentAcyltransferasesAnimalsEthanolHumansLiverMaleMiceMice, TransgenicOxidative StressAcyltransferasesEthanolLipaseMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, mouse

Identifiers

PMID40350061
PMCPMC12413239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.