Evidence map›Paper›PMID 40349963›Full record

ReviewThe journal of allergy and clinical immunology. In practice2025

Optimizing Pediatric Asthma Management: Implementation and Evaluation of Anti-Inflammatory Reliever and Single Maintenance and Reliever Therapies.

Thinh H Nguyen, Megan Elios, Anne M Fitzpatrick, Sharmilee M Nyenhuis, Wanda Phipatanakul

Abstract readReview
In one paragraph

Review in The journal of allergy and clinical immunology. In practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Clinician and family perspectives on the use of single maintenance and reliever therapy for children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thinh H NguyenDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Megan EliosDivision of Allergy and Immunology, Department of Pediatrics, University of Chicago, Chicago, Ill.
Anne M FitzpatrickDivision of Pulmonology, Department of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, Ga.
Sharmilee M NyenhuisDivision of Allergy and Immunology, Department of Pediatrics, University of Chicago, Chicago, Ill.
Wanda PhipatanakulDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address: wanda.phipatanakul@childrens.harvard.edu.

Funding

MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
Mentored patient-oriented research in preschool wheezing disordersK24NR018866 · NINR · EMORY UNIVERSITY · PI FITZPATRICK, ANNE MENTRO · 2020 to 2024
$625k
NIAID NIH HHS K24 AI106822NIAID NIH HHS T32 AI007512NINR NIH HHS K24 NR018866
6 · The paper itself

Abstract

Asthma is one of the most prevalent chronic disorders in children. Anti-inflammatory reliever (AIR) therapy and single maintenance and reliever therapy (SMART) have been adopted into the asthma management of adolescents and adults. However, limited evidence and guidance are currently available for asthma management of younger children with AIR therapy and SMART. Despite the potential benefits of these therapies, the evidence supporting their safety and efficacy in early childhood is evolving. Our review summarizes the current evidence regarding the risks and benefits of AIR therapy and SMART. Moreover, we also identified commonly known challenges of adopting AIR therapy and SMART for younger children as well as proposed potential solutions. Our review aims to offer a foundation for future research and clinical guidance to serve younger patients who could benefit from AIR therapy and SMART. This insight could ultimately lead to safer, more effective, and widely accessible asthma management options for children.

Indexed as

Anti-Asthmatic AgentsAnti-Inflammatory AgentsAsthmaAdolescentChildChild, PreschoolHumansAnti-Asthmatic AgentsAnti-Inflammatory AgentsAnti-inflammatory reliever therapyasthma controlAsthma treatment guidelinesBarriers to AIR and SMARTInhaled corticosteroids in childrenPediatric asthma managementShort-acting β(2)-agonistsSingle maintenance and reliever therapy

Identifiers

PMID40349963
PMCPMC12240706

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.