Evidence map›Paper›PMID 40349899›Full record

ArticleActa biomaterialia2025

Multiscale characterization of ultrasmall fluorescent core-shell silica nanoparticles in cartilage and synovial joints reveals rapid cartilage penetration and sustained joint residence.

Aiyana G Fortin, Nada Naguib, Erica J Secor, Heidi L Reesink, Ulrich B Wiesner, Lawrence J Bonassar

Abstract read
In one paragraph

Article in Acta biomaterialia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aiyana G FortinMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States.
Nada NaguibMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States.
Erica J SecorCollege of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Heidi L ReesinkCollege of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Ulrich B WiesnerMaterials Science and Engineering, Cornell University, Ithaca, NY, United States.
Lawrence J BonassarMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, United States. Electronic address: lb244@cornell.edu.

Funding

Graduate Training Program in Comparative MedicineT32OD011000 · OD · CORNELL UNIVERSITY · PI Amanda Marjorie DE MESTRE · 2012 to 2026
$5.7M
Broad wavelength range Zeiss 780 NLO/confocal system for the Cornell Imaging CoreS10OD018516 · OD · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2014 to 2014
$834k
In Vivo Optical and MicroCT Imaging Instruments for the Cornell BRC Imaging FacilityS10OD025049 · OD · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2018 to 2018
$750k
Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
National Science Foundation DGE – 2139899NCRR NIH HHS S10 RR025502New York State Stem Cell Science Program C029155NIH HHS S10 OD018516NIH HHS S10 OD025049NIH HHS T32 OD011000
6 · The paper itself

Abstract

Development of non-surgical disease-modifying interventions for knee osteoarthritis (OA) remains a persistent challenge despite decades of efforts. Therapeutic transport to cartilage in synovial joints is hindered by the dense, negatively charged cartilage matrix, and further challenged by rapid synovial fluid clearance within hours to days. In this study, we investigated ultrasmall (d

Indexed as

Cartilage, ArticularFluorescent DyesKnee JointNanoparticlesSilicon DioxideSynovial MembraneAnimalsChondrocytesHumansFluorescent DyesSilicon DioxideCartilageInjectionIntra-articularOsteoarthritisPharmacokineticsSilica nanoparticles

Identifiers

PMID40349899
PMCPMC12539274

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.