ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2026
Liver Transplantation Is Associated With a Reduced Risk of Colorectal Dysplasia in Patients With IBD and Concomitant PSC.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Beyond the Graft: Optimizing Post-Transplant Care in Primary Sclerosing Cholangitis.Journal of clinical medicine · 2026Review
- Evaluation and management of primary sclerosing cholangitis patients awaiting liver transplantation.JHEP reports : innovation in hepatology · 2026Review
- Colitis-Associated Carcinoma: The Quintessential Epithelial Neoplasia Driven by Chronic Inflammation.Cells · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
backgroundPrimary sclerosing cholangitis (PSC) affects up to 8% of patients with inflammatory bowel diseases (IBD) (Crohn's disease and ulcerative colitis) and is associated with an increased risk of colorectal neoplasia (CRN), which may be in part due to altered bile acid composition. About 40% of patients with PSC undergo liver transplantation.
objectiveThe study sought to examine whether liver transplantation modifies risk of colorectal cancer in patients with PSC and IBD.
methodsThis was a multi-institution retrospective cohort study comparing colon dysplasia/cancer in patients with PSC-IBD who underwent a liver transplantation with those with PSC-IBD without a liver transplant. Our primary outcome was the development of flat or visible colon cancer, low-grade dysplasia, or high-grade dysplasia. Multivariable regression models adjusting for relevant confounders examined effect of liver transplantation on cancer/dysplasia occurrence.
resultsOur study cohort consisted of 320 patients with PSC-IBD with a liver transplant compared with 659 PSC-IBD control subjects without a liver transplant. Most (80%) had ulcerative colitis. During follow-up, 239 (24%) patients developed CRN. On multivariable analysis, adjusting for age, sex, study site, duration of disease, and type of IBD, liver transplantation was associated with a lower risk of colon dysplasia or cancer (odds ratio, 0.66; 95% confidence interval, 0.47-0.93). The findings were unchanged on adjusting for number of surveillance exams, chromoendoscopy, or presence of endoscopically active disease. Dysplasia was more common in patients who developed recurrent PSC after transplantation.
conclusionsLiver transplantation was associated with a reduced risk of colon cancer/dysplasia in patients with PSC-IBD in our cohort.
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