Biological insights from integrative modeling of intrinsically disordered protein systems.

Zi Hao Liu, Maria Tsanai, Oufan Zhang, Teresa Head-Gordon, Julie D Forman-Kay

Abstract readReview

In one paragraph

Review in Current opinion in structural biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

HyRes: Accurate Physics-Based Simulation of Dynamic Protein Structures and Interactions in Complex Environments at Scale.bioRxiv : the preprint server for biology · 2026
Article
AlphaFlex: Ensembles of the human proteome representing disordered regions.bioRxiv : the preprint server for biology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zi Hao LiuMolecular Medicine Program, Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

Maria TsanaiPitzer Center for Theoretical Chemistry, University of California, Berkeley, CA, 94720, United States; Department of Chemistry, University of California, Berkeley, CA, 94720-1460, United States.

Oufan ZhangPitzer Center for Theoretical Chemistry, University of California, Berkeley, CA, 94720, United States; Department of Chemistry, University of California, Berkeley, CA, 94720-1460, United States.

Teresa Head-GordonPitzer Center for Theoretical Chemistry, University of California, Berkeley, CA, 94720, United States; Department of Chemistry, University of California, Berkeley, CA, 94720-1460, United States; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, 94720-1462, United States; Department of Bioengineering, University of California, Berkeley, CA, 94720-1762, United States.

Julie D Forman-KayMolecular Medicine Program, Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address: forman@sickkids.ca.

Funding

Calculating Ensembles of Discrete Dynamic Complexes and Condensed States of Intrinsically Disordered ProteinsR01GM127627 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Teresa L. Head-Gordon · 2018 to 2026

$2.1M

NIGMS NIH HHS R01 GM127627

6 · The paper itself

Abstract

Intrinsically disordered proteins and regions are increasingly appreciated for their abundance in the proteome and the many functional roles they play in the cell. In this short review, we describe a variety of approaches used to obtain biological insight from the structural ensembles of disordered proteins, regions, and complexes and the integrative biology challenges that arise from combining diverse experiments and computational models. Importantly, we highlight findings regarding structural and dynamic characterization of disordered regions involved in binding and phase separation, as well as drug targeting of disordered regions, using a broad framework of integrative modeling approaches.

Indexed as

Intrinsically Disordered ProteinsModels, MolecularHumansProtein BindingProtein ConformationIntrinsically Disordered Proteins

Identifiers

PMID40349675

DOI10.1016/j.sbi.2025.103063

PMCPMC12832064

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.