ReviewCurrent opinion in neurobiology2025
The role of the gut-brain axis in bariatric surgery.
Review in Current opinion in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Baseline Mental Health Status and Early Psychiatric Outcomes after Metabolic-Bariatric Surgery: A Retrospective Cohort Study.Obesity surgery · 2026Article
- Dysregulated glucagon signaling contributes to hypoglycemia after vertical sleeve gastrectomy in mice.Molecular metabolism · 2026Article
- Ghrelin and LEAP2: Their Interaction Effect on Appetite Regulation and the Alterations in Their Levels Following Bariatric Surgery.Medicina (Kaunas, Lithuania) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Bariatric surgery is the gold standard for sustained weight loss. Despite common misconceptions, bariatric surgery remodels gut-brain physiology in more complex ways than simply reducing stomach size or causing nutrient malabsorption. Bariatric surgery induces weight loss primarily by reductions in food intake and alterations in feeding patterns, macronutrient preference, and the rewarding aspects of food. Bariatric surgery also enhances nutrient-induced brain activation, alters nutrient processing, enhances gut hormone secretion, and increases bile acids. However, which of these signals directly link to improved satiety and altered reward pathways remains unclear. While state-of-the-art tools are now available to manipulate specific subpopulations of peripheral sensory neurons, work is needed to apply these tools to obesity and bariatric surgery. This will be critical for advancing the understanding of the role of the gut-brain axis in the success of surgery and allowing for the continued expansion of therapeutic options for obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.