Evidence map›Paper›PMID 40349545›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Visualization of functional and effective connectivity underlying auditory descriptive naming.

Yu Kitazawa, Kazuki Sakakura, Hiroshi Uda, Naoto Kuroda, Riyo Ueda, Ethan Firestone, Min-Hee Lee, Jeong-Won Jeong, Masaki Sonoda, Shin-Ichiro Osawa and 12 more

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Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yu KitazawaDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurology and Stroke Medicine, Yokohama City University, Yokohama, Kanagawa 2360004, Japan.
Kazuki SakakuraDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurosurgery, University of Tsukuba, Tsukuba, Ibaraki 3058575, Japan; Department of Neurosurgery, Rush University Medical Center, Chicago, IL 60612, USA.
Hiroshi UdaDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurosurgery, Osaka Metropolitan University Graduate School of Medicine, Osaka 5458585, Japan.
Naoto KurodaDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Riyo UedaDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Epilepsy Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 1878551, Japan.
Ethan FirestoneDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Physiology, Wayne State University, Detroit, MI 48201, USA.
Min-Hee LeeDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA.
Jeong-Won JeongDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA.
Masaki SonodaDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurosurgery, Yokohama City University, Yokohama, Kanagawa 2360004, Japan.
Shin-Ichiro OsawaDepartment of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai 9808574, Japan.
Kazushi UkishiroDepartment of Epileptology, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Makoto IshidaDepartment of Epileptology, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Kazuo KakinumaDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Shoko OtaDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Yutaro TakayamaDepartment of Neurosurgery, Yokohama City University, Yokohama, Kanagawa 2360004, Japan; Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 1878551, Japan.
Keiya IijimaDepartment of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 1878551, Japan.
Toshimune KambaraDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Psychology, Hiroshima University, Hiroshima 7398524, Japan.
Hidenori EndoDepartment of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai 9808574, Japan.
Kyoko SuzukiDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Nobukazu NakasatoDepartment of Epileptology, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Masaki IwasakiDepartment of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 1878551, Japan.
Eishi AsanoDepartment of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Neurology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Pediatrics, Central Michigan University, Mt. Pleasant, MI 48858, USA. Electronic address: easano@med.wayne.edu.

Funding

Functional brain mapping in pediatric neurosurgeryR01NS064033 · NINDS · WAYNE STATE UNIVERSITY · PI EISHI ASANO · 2009 to 2026
$5.7M
Novel DWI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery.R01NS089659 · NINDS · WAYNE STATE UNIVERSITY · PI JEONG, JEONG-WON · 2015 to 2025
$3.7M
Intraoperative Localization of Epileptic Brain Regions Under Sevoflurane Anesthesia.F30NS129239 · NINDS · WAYNE STATE UNIVERSITY · PI FIRESTONE, ETHAN JOSEPH · 2023 to 2024
$101k
NINDS NIH HHS F30 NS129239NINDS NIH HHS R01 NS064033NINDS NIH HHS R01 NS089659
6 · The paper itself

Abstract

objectiveWe visualized functional and effective connectivity within specific white matter networks in response to auditory descriptive questions.

methodsWe investigated 40 Japanese-speaking patients with focal epilepsy and estimated connectivity measures using cortical high-gamma dynamics and MRI tractography.

resultsHearing a wh-interrogative at question onset enhanced inter-hemispheric functional connectivity, with left-to-right callosal facilitatory flows between the superior-temporal gyri, contrasted by functional connectivity diminution with right-to-left callosal suppressive flows between dorsolateral prefrontal regions. Processing verbs associated with concrete objects or adverbs increased left intra-hemispheric connectivity, with bidirectional facilitatory flows through extensive white matter pathways. Questions beginning with what, compared to where, induced greater neural engagement in the left posterior inferior-frontal gyrus at question offset, linked to enhanced functional connectivity and bidirectional facilitatory flows to the temporal lobe neocortex via the arcuate fasciculus. During overt responses, inter-hemispheric functional connectivity was enhanced, with bidirectional callosal flows between Rolandic areas, and individuals with higher IQ scores exhibited less prolonged neural engagement in the left posterior middle frontal gyrus.

conclusionsVisualization of directional neural interactions within white matter networks during overt naming is feasible. SIGNIFICANCE: Phrase order may influence network dynamics in listeners, even when presented with auditory descriptive questions conveying similar meanings.

Indexed as

Auditory PerceptionNerve NetWhite MatterAcoustic StimulationAdultBrain MappingDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung AdultDynamic tractographyEpilepsy surgeryFunctional brain mappingIntracranial electroencephalography (EEG)LanguageSpeech

Identifiers

PMID40349545
PMCPMC12178814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.