ArticleCell reports2025
Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- Propofol-induced loss of responsiveness reorganizes cortical traveling waves in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Parabiosis, Assembloids, Organoids (PAO).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Organizational closure through regenerative signaling as a possible basis for conscious awareness.Frontiers in computational neuroscience · 2026Review
- A Dual-Mode Wireless Microsystem for Monitoring Dopamine and Spike Changes with Dexmedetomidine.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Neural models for detection and classification of brain states and transitions.Communications biology · 2025Article
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8 authors.
Funding
Abstract
Many anesthetics cause loss of consciousness despite having diverse underlying molecular and circuit actions. To explore the convergent effects of these drugs, we examine how anesthetic doses of ketamine and dexmedetomidine affect bilateral oscillations in the prefrontal cortex of nonhuman primates. Both anesthetics increase phase locking in the ventrolateral and dorsolateral prefrontal cortex, within and across hemispheres. However, the nature of the phase locking varies. Neighboring prefrontal subregions within a hemisphere show decreased phase alignment with both drugs. Local analyses within a region suggest that this finding could be explained by broad cortical distance-based effects, such as large traveling waves. In contrast, homologous areas across hemispheres become more aligned in phase. Our results suggest that both anesthetics induce strong patterns of cortical phase alignment that are markedly different from those during waking and that these patterns may be a common feature driving loss of responsiveness from different anesthetic drugs.
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