Evidence map›Paper›PMID 40349325›Full record

Trial reportThe Journal of physiology2026

Acute ketone monoester ingestion lowers resting cerebral blood flow: a randomized cross-over trial.

Aedan J Rourke, Claudia M S Yong, Geoff B Coombs, Addriana R Odisho, Jenna A Nash, Jack Bone, Baraa K Al-Khazraji, Jeremy J Walsh

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aedan J RourkeDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.ORCID 0009-0009-9858-705X
Claudia M S YongDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Geoff B CoombsDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Addriana R OdishoDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Jenna A NashDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Jack BoneDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.ORCID 0009-0004-7816-0546
Baraa K Al-KhazrajiDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-1075-4183
Jeremy J WalshDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-1782-7074

Funding

Canadian Foundation for Innovation John R. Evans Leaders Fund 41305Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) 202103522
6 · The paper itself

Abstract

Exogenous ketone monoester (KME) supplements rapidly increase plasma beta-hydroxybutyrate (β-OHB) and may impact cerebral blood flow (CBF). However, it is currently unknown how acute KME ingestion impacts resting CBF and whether differences in KME dose have differential effects on CBF regulation. The purpose of this study was to investigate the effect of two separate KME doses on resting CBF in young adults. On separate days and in a double-blind, placebo-controlled, cross-over design, 20 participants (10 females; aged 23 ± 3 years) ingested either: (1) High-KME (0.6 g kg

Indexed as

Cerebrovascular CirculationKetones3-Hydroxybutyric AcidAdultCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle Cerebral ArteryYoung Adult3-Hydroxybutyric AcidKetonesbeta‐hydroxybutyratecardiorespiratory stresscerebral blood flowcerebrovasculardose–responsedouble‐blindend‐tidal CO2exogenous ketone supplementsplacebo‐controlled

Identifiers

PMID40349325
PMCPMC12997017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.