ArticleThe Journal of physiology2025
Varied ionic currents underlie functional diversity of hypoglossal motoneurons innervating the superior longitudinalis and genioglossus tongue muscles.
Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The evidence for old age motor neuron death: A scoping review.Physiological reports · 2026Article
- Structural and mitochondrial dendritic degenerations in old hypoglossal motor neurons.GeroScience · 2026Article
- On the concept of 'mild motor impairment': A neuromotor harbinger of sarcopenia and frailty?The Journal of physiology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Hypoglossal motoneurons (XIIMNs) control tongue movement, which must be precisely coordinated for communication, swallowing and respiration. We previously found that XIIMNs innervating intrinsic and extrinsic tongue muscles exhibit diverse firing properties. Here we investigate the mechanisms behind functional differences of XIIMNs that control the superior longitudinalis (SL) and genioglossus (GG) muscles, which retract and protrude the tongue, respectively. We hypothesized that varied ionic currents drive muscle-specific firing properties in XIIMNs. We obtained whole-cell patch-clamp recordings from retrogradely labelled SL and GG XIIMNs obtained from male and female neonatal rats. SL and GG XIIMNs exhibited distinct firing patterns, and SL XIIMNs had higher intrinsic excitability than GG XIIMNs. Next, voltage-clamp studies aimed to determine the ionic mechanisms responsible for functional differences between SL and GG XIIMNs. While whole-cell K
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