Evidence map›Paper›PMID 40349310›Full record

ArticleExperimental physiology2025

TRPV1 blockade restores the baroreflex control of renal sympathetic nerve activity in cisplatin-induced renal injury in rats.

Mohammed H Abdulla, Ella Murphy, Lauren Mulcahy, Edward J Johns

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohammed H AbdullaDepartment of Physiology, University College Cork, Cork, Ireland.ORCID https://orcid.org/0000-0001-5496-5017
Ella MurphyDepartment of Physiology, University College Cork, Cork, Ireland.
Lauren MulcahyDepartment of Physiology, University College Cork, Cork, Ireland.
Edward J JohnsDepartment of Physiology, University College Cork, Cork, Ireland.ORCID https://orcid.org/0000-0001-8344-7059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal injury is associated with inflammatory responses within the kidney which could involve activation of transient receptor potential vanilloid 1 (TRPV1) channels. This study investigated whether TRPV1 channels modulate baroreflex regulation of renal sympathetic nerve activity (RSNA) in a rat model of cisplatin-mediated renal injury. Rats were anaesthetised and prepared for measurement of mean arterial pressure (MAP), heart rate (HR) and RSNA 4 days after a single i.p. dose of cisplatin (5 mg kg

Indexed as

Acute Kidney InjuryBaroreflexCisplatinKidneySympathetic Nervous SystemTRPV Cation ChannelsAnimalsBlood PressureCapsaicinHeart RateMaleRatsRats, Sprague-DawleyCapsaicincapsazepineCisplatinTrpv1 protein, ratTRPV Cation Channelsbaroreflexcapsazepinecisplatinrenal sympathetic nerve activityTNF‐α

Identifiers

PMID40349310
PMCPMC12665942

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.