Evidence map›Paper›PMID 40349256›Full record

ArticleJournal of anesthesia2025

A dose-ranging pilot trial of dexmedetomidine-propofol in children undergoing magnetic resonance imaging.

Samuel Y Kim, Jocelyn M Booth, Steven J Staffa, Anna Kordun, Jane Yu, Joseph P Cravero

Registry-linked trialAbstract read
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In one paragraph

Article in Journal of anesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07369128 (A Randomized, Dose-Ranging Trial of Propofol-Only and Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07369128 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized, Dose-Ranging Trial of Propofol-Only and Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging

TypeinterventionalSponsorBoston Children's HospitalRan2026 to 2028Enrolled105ConditionsMRI Sedation, Pediatric Sedation, Propofol Dosage, Emergence Delirium, AnesthesiaArmsDexmedetomidine (IV) 0.5 mcg/kg, Propofol (IV) 2-4 mg/kg, Dexmedetomidine (IV) 1 mcg/kg, Propofol (IV) 1-2 mg/kg, Propofol (IV) Infusion 250 mcg/kg/min
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. How can children benefit from total-body PET?The British journal of radiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samuel Y KimDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA. samuel.kim@childrens.harvard.edu.ORCID http://orcid.org/0009-0008-0407-4919
Jocelyn M BoothDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Steven J StaffaDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Anna KordunDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Jane YuDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Joseph P CraveroDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optimal sedation/anesthesia technique for magnetic resonance imaging (MRI) scans has not been established. The combination of propofol with dexmedetomidine has been reported, but without systematic dosing data. Our primary aim was to determine the propofol-sparing effect of dexmedetomidine (DEX) when added to propofol for MRI scan sedation/anesthesia utilizing a dose-ranging protocol for four distinct regimens (Propofol-Only, DEX-High, DEX-Low, DEX-Bolus). Our secondary aims were to document adverse events, scan interruptions due to patient movements, and determine recovery time. Seventy-nine patients aged 1-12 years scheduled for MRIs under anesthesia were sequentially enrolled. A 60% reduction in propofol dose required was found in the dexmedetomidine cohorts. There was no difference (p = 0.161) in recovery time between Propofol-Only and DEX-Bolus groups. There were no differences in episodes of hypotension (p = 0.464), bradycardia (p = 0.558), or patient movement (p = 0.273) between the Propofol-Only and dexmedetomidine cohorts. Recovery time was prolonged for DEX-High and DEX-Low groups compared to DEX-Bolus or Propofol-Only. The addition of dexmedetomidine significantly decreased the necessary dose of propofol. Propofol combined with a single bolus of dexmedetomidine (no infusion) provided effective sedation/anesthesia without adverse events or extending recovery time.

Indexed as

Anesthetics, IntravenousDexmedetomidineHypnotics and SedativesMagnetic Resonance ImagingPropofolAnesthesia Recovery PeriodChildChild, PreschoolDose-Response Relationship, DrugFemaleHumansInfantMalePilot ProjectsAnesthetics, IntravenousDexmedetomidineHypnotics and SedativesPropofolDexmedetomidineMRIPediatricsPropofolSedation

Identifiers

PMID40349256

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.