Evidence map›Paper›PMID 40349215›Full record

ArticleACS infectious diseases2025

Validation of a Cystic Fibrosis Co-Culture Model for the Identification of Dual Acting Compounds with Antibiotic and Antibiotic Adjuvant Properties.

Anne E Mattingly, Haoting Li, Roberta J Melander, Christian Melander

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genome sequences of two highly colistin-resistantMicrobiology resource announcements · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anne E MattinglyDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame 46556, Indiana, United States.
Haoting LiDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame 46556, Indiana, United States.
Roberta J MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame 46556, Indiana, United States.
Christian MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame 46556, Indiana, United States.ORCID 0000-0001-8271-4696

Funding

Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
Development of Antibiotic Adjuvants for Gram-Negative BacteriaR01AI136904 · NIAID · UNIVERSITY OF NOTRE DAME · PI MELANDER, CHRISTIAN COREY · 2018 to 2022
$3.7M
NIAID NIH HHS R01 AI104895NIAID NIH HHS R01 AI136904
6 · The paper itself

Abstract

Infections in the lungs of cystic fibrosis (CF) patients are often polymicrobial in nature, typically comprising

Indexed as

Anti-Bacterial AgentsCystic FibrosisPseudomonas aeruginosaStaphylococcus aureusCoculture TechniquesColistinDrug SynergismHumansMicrobial Sensitivity TestsPseudomonas InfectionsSputumStaphylococcal InfectionsAnti-Bacterial AgentsColistinadjuvantantibioticco-culturecystic fibrosisPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID40349215
PMCPMC12530260

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.