ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Manganese-Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A general photoinduced manganese-catalyzed platform for the sequential difunctionalization of [1.1.1]propellane.Science advances · 2026Article
- Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late-Stage Modification of Drugs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Manganese-Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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6 authors.
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Abstract
Dehydroalanine (Dha), a readily introducible non-canonical amino acid, is widely used for protein post-translational modification (PTM) and site-specific labeling of peptides and proteins. Despite its growing applications in biological systems, the precise modification of unnatural amino acid peptides and their conversion into functionalized endogenous peptides remain underdeveloped. To address this challenge, a novel peptide modification strategy is developed based on a manganese-catalyzed electrochemical radical relay process between dehydroalanine peptides and sodium azide. This method demonstrates excellent functional group tolerance, accommodating amino acids with sensitive groups and even drug molecules, achieving yields of up to 99%. Mechanistic studies reveal that the reaction proceeds via a Mn(II)-mediated electrochemical generation of azidyl radicals (N
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