Evidence map›Paper›PMID 40349045›Full record

ArticleClinical epigenetics2025

Maternal asthma and newborn DNA methylation.

Casper-Emil Tingskov Pedersen, Thanh T Hoang, Jianping Jin, Anna Starnawska, Raquel Granell, Hannah R Elliott, Anke Huels, Heather J Zar, Dan J Stein, Yining Zhang and 37 more

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In one paragraph

Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Casper-Emil Tingskov PedersenCopenhagen Prospective Studies On Asthma in Childhood, Herlev and Gentofte Hospital, COPSAC, University of Copenhagen, Ledreborg Alle 34 Gentofte, 2820, Copenhagen, Denmark.
Thanh T HoangDivision of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), MD A3-05, PO 12233, Research Triangle Park, NC, 27709, USA.
Jianping JinDivision of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), MD A3-05, PO 12233, Research Triangle Park, NC, 27709, USA.
Anna StarnawskaDepartment of Biomedicine, Aarhus University, 8000, Aarhus, Denmark.
Raquel GranellDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
Hannah R ElliottDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
Anke HuelsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Heather J ZarSAMRC Unit On Child & Adolescent Health, Dept of Paediatrics, University of Cape Town, Cape Town, South Africa.
Dan J SteinSAMRC Unit On Child & Adolescent Health, Dept of Paediatrics, University of Cape Town, Cape Town, South Africa.
Yining ZhangDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Herman T den DekkerThe Generation R Study Group and Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Liesbeth DuijtsThe Generation R Study Group and Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Janine F FelixThe Generation R Study Group and Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Júlia SangüesaISGlobal, Barcelona, Spain.
Mariona BustamanteISGlobal, Barcelona, Spain.
Maribel CasasISGlobal, Barcelona, Spain.
Martine VrijheidISGlobal, Barcelona, Spain.
Latha KadalayilSchool of Chemistry, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, UK.
Faisal I RezwanDepartment of Computer Science, Aberystwyth University, University, Aberystwyth, SY23 3DB, UK.
Hasan ArshadDavid Hide Asthma and Allergy Research Centre, Isle of Wight, UK.
John W HollowayFaculty of Medicine, Human Development and Health, University of Southampton, Southampton, UK.
Stefan RöderDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Ana C ZenclussenDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Gunda HerberthDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Nicklas Heine StaunstrupDepartment of Biomedicine, Aarhus University, 8000, Aarhus, Denmark.
Henriette Thisted HorsdalThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Jonathan MillDepartment of Clinical & Biomedical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK.
Eilis HannonDepartment of Clinical & Biomedical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK.
iPSYCH-MINERvA Group
Isabella Annesi-MaesanoInstitute Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Montpellier, France.
Giancarlo PesceInstitute Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Montpellier, France.
Nour BaïzInstitute Desbrest of Epidemiology and Public Health, University of Montpellier and INSERM, Montpellier, France.
Barbara HeudeInserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), Université Paris Cité and Université Sorbonne Paris Nord, 75004, Paris, France.
Sahra Hosseinian-MohazzabDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Carrie V BretonDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Sophia HarlidDepartment of Diagnostics and Intervention, Oncology, Umeå University, Umeå, Sweden.
Justin HarbsDepartment of Diagnostics and Intervention, Oncology, Umeå University, Umeå, Sweden.
Magnus DomellofDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Christina WestDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Edwina YeungEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, 20817, USA.
Xuehuo ZengGlotech Inc., 1801 Research Blvd #605, Rockville, MD, 20850, USA.
Wenche NystadDepartment of Chronic Diseases, Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.
Siri E HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, Skøyen, P.O. Box 222, 0213, Oslo, Norway.
Maria C MagnusDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
Diana SchendelThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Stephanie J London *Division of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), MD A3-05, PO 12233, Research Triangle Park, NC, 27709, USA. london2@niehs.nih.gov.
Klaus Bønnelykke *Copenhagen Prospective Studies On Asthma in Childhood, Herlev and Gentofte Hospital, COPSAC, University of Copenhagen, Ledreborg Alle 34 Gentofte, 2820, Copenhagen, Denmark. kb@copsac.com.

Funding

European Union's Horizon 2020 research and innovation programme 733206Intramural Research Program of the NIH 49019Lundbeck Foundation R16-A1694Medical Research Council and the University of Bristol MC_UU_00011/5Strategiske Forskningsråd 0603-00280BThe ministry of health, Denmark 903516
6 · The paper itself

Abstract

backgroundPrenatal exposure to maternal asthma may influence DNA methylation patterns in offspring, potentially affecting their susceptibility to later diseases including asthma.

objectiveTo investigate the relationship between parental asthma and newborn blood DNA methylation.

methodsEpigenome-wide association analyses were conducted in 13 cohorts on 7433 newborns with blood methylation data from the Illumina450K or EPIC array. We used fixed effects meta-analyses to identify differentially methylated CpGs (DMCs) and comb-p to identify differentially methylated regions (DMRs) associated with maternal asthma during pregnancy and maternal asthma ever. Paternal asthma was analyzed for comparison. Models were adjusted for covariates and cell-type composition. We examined whether implicated sites related to gene expression analyses in publicly available data for childhood blood and adult lung.

resultsWe identified 27 CpGs associated with maternal asthma during pregnancy at False Discovery Rate < 0.05 but none for maternal asthma ever. Two distinct CpGs were associated with paternal asthma. We observed 5 DMRs associated with maternal asthma during pregnancy 3 associated with maternal asthma ever and 13 DMRs associated with paternal asthma. Gene expression analysis using data in blood from 832 children and lung from 424 adults showed associations between identified DMCs using maternal asthma and expression of several genes, including HLA genes and HOXA5, previously implicated in asthma or lung function.

conclusionParental asthma, especially maternal asthma during pregnancy, may be associated with alterations in newborn DNA methylation. These findings might shed light on underlying mechanisms for asthma susceptibility.

Indexed as

AsthmaDNA MethylationPregnancy ComplicationsPrenatal Exposure Delayed EffectsAdultCpG IslandsEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansInfant, NewbornMalePregnancy

Identifiers

PMID40349045
PMCPMC12065361

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