Evidence map›Paper›PMID 40348947›Full record

ArticleBMC medical research methodology2025

A new framework for disentangling different components of excess mortality applied to Dutch care home residents during Covid-19.

Marije H Sluiskes, Eva A S Koster, Jelle J Goeman, Mar Rodríguez-Girondo, Hein Putter, Liesbeth C de Wreede

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Article in BMC medical research methodology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Marije H SluiskesMedical Statistics, Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. m.h.sluiskes@lumc.nl.
Eva A S KosterMedical Statistics, Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Jelle J GoemanMedical Statistics, Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Mar Rodríguez-GirondoMedical Statistics, Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Hein PutterMedical Statistics, Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Liesbeth C de WreedeMedical Statistics, Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. l.c.de_wreede@lumc.nl.

Funding

ZonMw 10430252220011
6 · The paper itself

Abstract

backgroundVulnerable subgroups of the population, such as care home residents, often face elevated mortality risks during crises like pandemics or wars. To correctly model and interpret the excess mortality of vulnerable groups during crises, a distinction must be made between the pre-existing heightened mortality of the vulnerable group, the general population's excess mortality during the crisis, and the crisis-specific excess mortality unique to the vulnerable group.

methodsWe introduce the concept of "excess excess" mortality, which captures the extra excess mortality experienced by vulnerable groups during crises, beyond what can be explained by their excess mortality due to being vulnerable and general population excess mortality. Using individual-level data from Statistics Netherlands, we model the excess excess mortality of Dutch care home residents aged 70 and older during the Covid-19 pandemic. We extend standard relative survival methods by incorporating multiple excess mortality components and use an additive hazards model to accommodate periods of negative excess hazard.

resultsThe findings confirm the severe impact of the Covid-19 pandemic on care home residents. In general, men and older age groups experienced higher excess excess mortality, both in absolute and relative terms.

conclusionsOur approach offers a new perspective on how to model and interpret excess mortality in vulnerable groups during a crisis and provides a methodological foundation for investigating excess excess mortality in other contexts.

Indexed as

COVID-19Homes for the AgedNursing HomesAgedAged, 80 and overFemaleHumansMaleMortalityNetherlandsPandemicsSARS-CoV-2Vulnerable PopulationsAdditive hazardsCare homesCovid-19Excess mortalityRelative survival

Identifiers

PMID40348947
PMCPMC12065346

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.