ArticleCommunications biology2025
Neural representation of self-initiated locomotion in the secondary motor cortex of mice across different environmental contexts.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Exercise as a Neurobiological Intervention: Utilizing NAc Circuitry to Combat Addiction.Addiction neuroscience · 2026Article
- A transparent wheel-based platform for locomotion-on-demand and multi-view body and facial kinematics in head-fixed mice.Scientific reports · 2026Article
- Widefield cortical activity and functional connectivity during motorized locomotion.Communications biology · 2026Article
- Knockout of Bmal1 in dopaminergic neurons induces ADHD-like symptoms via hyperactive dopamine signaling in male mice.Behavioral and brain functions : BBF · 2025Article
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Authors and funding
11 authors.
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Abstract
The secondary motor cortex (M2) plays an important role in the adaptive control of locomotor behaviors. However, it is unclear how M2 neurons encode the same type of locomotor control variables in different environmental contexts. Here we image the neuronal activity in M2 with a miniscope while mice are moving freely in each of three environments: a Y-maze, a running-wheel, and an open-field. These animals show distinct locomotor patterns in different environmental contexts. Surprisingly, a large population of M2 neurons are active before starting and after ceasing locomotion, while maintaining decreased neural activity during locomotion. Furthermore, the majority of these neurons are consistently engaged across various contexts, suggesting egocentric voluntary control functions. In contrast, the smaller populations of locomotion-activated M2 neurons are mostly context-specific, suggesting exocentric navigation functions. Thus, our results demonstrate that M2 neurons encode motor control variables for self-initiated locomotor behaviors in both context-dependent and context-independent manners.
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