ArticleScientific reports2025
The identity of implant materials governs the antimicrobial efficacy of SET-M33.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- PrismaLuc luciferase enables tunable near-infrared bioluminescence forRSC chemical biology · 2026Article
- Cooperative Oligomeric Peptide Combinations Enhance the Predicted Therapeutic Profile of SET-M33.Antibiotics (Basel, Switzerland) · 2026Article
- Article
- Bridging biology and technology: the rise of 3D bioprinting advancements in infection research.Frontiers in bioengineering and biotechnology · 2026Review
- Preclinical evaluation of a compliant and absorbable cardiac implantable electronic device antibacterial envelope.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The physical and chemical properties of implanted materials play a key role in their interaction with synthetic peptides that exert antimicrobial activity. In this study, we explored the diffusion properties and efficacy of the SET-M33 antimicrobial peptide in combination with artificial substrates, comprising cardiac implantable electronic devices (CIEDs) or porous protective envelopes. We found that porous materials, such as biosynthesized cellulose, polymeric meshes, and electrospun membranes, were conducive to SET-M33 diffusion. The diffusion dynamics was controlled by the intrinsic fibrous architecture of the materials. Biosynthesized cellulose supported the peptide's antimicrobial activity against E. coli and S. aureus. The efficacy of SET-M33 was instead reduced when combined with the other tested porous membranes and non-porous CIED interfaces, such as titanium and silicone. On the other hand, the low porosity of biosynthesized cellulose membranes, while effective in retaining the drug, diminished diffusion and thus peptide availability. In light of these findings, the implications for the use of antimicrobial peptides in the prevention of CIED surgical pocket infections are discussed.
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Registered trials
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