Evidence map›Paper›PMID 40348824›Full record

ArticleScientific reports2025

Childhood abuse and neglect are differentially related to perceived discrimination and structural change in empathy-related circuitry.

Melike M Fourie, Fleur L Warton, Tess Derrick-Sleigh, Hannah Codrington, Mark Solms, Jean Decety, Dan J Stein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Melike M FourieDepartment of Surgery and Neuroscience Institute, University of Cape Town, Observatory, Cape Town, 7925, South Africa. marethem@gmail.com.ORCID http://orcid.org/0000-0003-4879-7250
Fleur L WartonBiomedical Engineering Research Centre, Department of Human Biology and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Tess Derrick-SleighDepartment of Psychology and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Hannah CodringtonDepartment of Psychology and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Mark SolmsDepartment of Psychology and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Jean DecetyDepartment of Psychology and Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.
Dan J SteinSAMRC Unit On Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Behavioral studies indicate that adverse childhood experiences (ACE) are associated with altered empathic responding, but the neural mechanisms underlying this relationship remain unclear. Given the significance of empathy in contexts marred by historical conflict and systemic inequality, work on these mechanisms is particularly important in such contexts. The current study extends previous work by (1) examining associations of different dimensions of ACE with volumetric change in empathy-related circuitry, (2) distinguishing between trait and state empathy, and (3) including perceived discrimination as an additional psychosocial stressor. Thirty-nine healthy South African adults from the general population (M

Indexed as

Adult Survivors of Child AbuseBrainChild AbuseEmpathyAdultAdverse Childhood ExperiencesChildFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedAdverse childhood experiencesChildhood abuseChildhood neglectEmpathyPerceived discriminationStructural MRI

Identifiers

PMID40348824
PMCPMC12065813

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.