Evidence map›Paper›PMID 40348752›Full record

ArticleNature communications2025

T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination.

Ji-Li Chen, Beibei Wang, Yongxu Lu, Elie Antoun, Olivia Bird, Philip G Drennan, Zixi Yin, Guihai Liu, Xuan Yao, Maya Pidoux and 19 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Ji-Li Chen *Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Beibei Wang *Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3746-0188
Yongxu Lu *Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-4701-5560
Elie Antoun *Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Olivia Bird *Oxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID http://orcid.org/0000-0002-4917-500X
Philip G Drennan *Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Zixi Yin *Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Guihai LiuChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Xuan YaoChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Maya PidouxChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Adam BatesChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-4241-2807
Deshni JayathilakaChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Junyuan WangChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Brian AngusNDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-3598-7784
Sally BeerOxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID http://orcid.org/0000-0002-0988-3458
Alexis EspinosaOxford University Hospitals NHS Foundation Trust, Oxford, UK.
J Kenneth BaillieBaillie Gifford Pandemic Science Hub, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5258-793X
Malcolm G SempleNIHR Health Protection Research Unit, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-9700-0418
ISARIC4C Investigators
Timothy RostronSequencing Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Craig WaughFlow Cytometry Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Paul SoppFlow Cytometry Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Julian C KnightChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0377-5536
James N FullertonOxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID http://orcid.org/0000-0002-4855-9255
Mark ColesKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-8079-9358
Geoffrey L SmithChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3730-9955
Alexander J MentzerChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4502-2209
Yanchun PengChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Tao DongChinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. tao.dong@ndm.ox.ac.uk.ORCID http://orcid.org/0000-0003-3545-3758

Funding

Research Training in Pediatric OncologyT32CA136432 · NCI · DANA-FARBER CANCER INST · PI SCOTT A ARMSTRONG · 2009 to 2026
$7.9M
NCI NIH HHS T32 CA136432Wellcome Trust
6 · The paper itself

Abstract

In 2022, a global mpox outbreak occurred, and remains a concern today. The T cell memory response to MPXV (monkeypox virus) infection has not been fully investigated. In this study, we evaluate this response in convalescent and MVA-BN (Modified Vaccinia Ankara - Bavarian Nordic) vaccinated individuals using VACV-infected cells. Strong CD8

Indexed as

Immunologic MemoryMemory T CellsMpox, MonkeypoxViral VaccinesAdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell MovementEpitopes, T-LymphocyteFemaleHumansImmunodominant EpitopesMaleSmallpox VaccineVaccinationVaccinia virusEpitopes, T-LymphocyteImmunodominant EpitopesSmallpox VaccineViral Vaccines

Identifiers

PMID40348752
PMCPMC12065855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.