ArticleAdvanced healthcare materials2025
Rod-shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Iron-dexamethasone nanoparticles mitigate acute neutrophilic inflammation.Bioengineering & translational medicine · 2026Article
- Harnessing Targeted Polymerized Salicylic Acid Particles to Mitigate Neutrophil-Driven Inflammation.ACS biomaterials science & engineering · 2026Article
- S100A12 as a key biomarker in a neutrophil-associated gene prediction model for sepsis diagnosis.Medicine · 2025Article
- Rod-shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation.Advanced healthcare materials · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
Neutrophilic inflammation is present in numerous high-mortality pathologies, including sepsis, deep vein thrombosis, and acute lung injury (ALI). Therefore, regulating neutrophil recruitment becomes an attractive therapeutic approach for neutrophil-mediated inflammation. Here, the impact of salicylic acid-based polymeric particles in regulating neutrophil recruitment in vivo and in vitro, particularly investigating the impact of neutrophil targeting via particle geometry-driven phagocytosis is explored. It is found that rod-shaped polymeric particles can improve neutrophil targeting in a murine ALI model, effectively preventing neutrophil infiltration into the mice's lungs compared to spherical particles of the same volume. It is demonstrated that the elongated nature of the polymeric carriers reduced neutrophils' transmigration ability across endothelial barriers in vivo and in vitro, contributing to their therapeutic effectiveness. These data represent initial work in developing non-spherical particle-mediated targeting of activated neutrophils for conditions affected by neutrophilic injury.
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Registered trials
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