Evidence map›Paper›PMID 40348602›Full record

ArticleHuman brain mapping2025

Brain Morphometry in Infants Later Diagnosed With Autism is Related to Later Language Skills.

Luke E Moraglia, Bernadette Weigman, Hervé Abdi, Martin Styner, Sun Hyung Kim, Catherine A Burrows, Mark D Shen, Shruthi Ravi, Jason J Wolff, Stephen R Dager and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Luke E MoragliaDepartment of Psychology, The University of Texas at Dallas, Richardson, Texas, USA.ORCID 0009-0005-9893-7807
Bernadette WeigmanDepartment of Psychology, The University of Texas at Dallas, Richardson, Texas, USA.
Hervé AbdiDepartment of Psychology, The University of Texas at Dallas, Richardson, Texas, USA.
Martin StynerDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
Sun Hyung KimDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
Catherine A BurrowsDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Mark D ShenDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
Shruthi RaviInstitute on Human Development and Disability, University of Washington, Seattle, Washington, USA.
Jason J WolffDepartment of Educational Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Stephen R DagerInstitute on Human Development and Disability, University of Washington, Seattle, Washington, USA.
Heather C HazlettDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
Juhi PandeyCenter for Autism Research, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robert T SchultzCenter for Autism Research, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jessica B GiraultDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
Kelly N BotteronDepartment of Psychiatry and Radiology, Washington University, St. Louis, Missouri, USA.
Natasha MarrusDepartment of Psychiatry and Radiology, Washington University, St. Louis, Missouri, USA.
Annette M EstesInstitute on Human Development and Disability, University of Washington, Seattle, Washington, USA.
Tanya St JohnInstitute on Human Development and Disability, University of Washington, Seattle, Washington, USA.
Guoyan ZhengInstitute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Joseph PivenDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
Meghan R SwansonDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
IBIS Network

Funding

Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Caregiver Speech and Brain-Behavior Development in Infants At-Risk for ASDR01DC019660 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI Meghan Rae Swanson · 2022 to 2026
$3.8M
Genetic Liability for Autism and Infant Brain and Behavioral DevelopmentK01MH122779 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GIRAULT, JESSICA BULLINS · 2020 to 2024
$919k
Early Social Communication Environment and Brain Development in Infants at Risk for AutismR00MH108700 · NIMH · UNIVERSITY OF TEXAS DALLAS · PI SWANSON, MEGHAN RAE · 2019 to 2021
$731k
Towards equitable early identification of autism spectrum disorders in femalesK23HD112507 · NICHD · UNIVERSITY OF MINNESOTA · PI Catherine Ann Burrows · 2023 to 2026
$459k
Early Social Communication Environment and Brain Development in Infants at Risk for AutismK99MH108700 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SWANSON, MEGHAN RAE · 2016 to 2017
$174k
NICHD NIH HHS K23 HD112507NICHD NIH HHS P50 HD103525NICHD NIH HHS R01 HD055741NIH HHS P50HD103573NIH HHS R01DC019660NIH HHS R01HD055741NIH HHS R01HD055741-S1NIMH NIH HHS K01 MH122779NIMH NIH HHS K99MH108700NIMH NIH HHS R00MH108700Simons Foundation SFARI 140209
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) presents early in life with distinct social and language differences. This study explores the association between infant brain morphometry and language abilities using an infant-sibling design. Participants included infants who had an older sibling with autism (high likelihood, HL) who were later diagnosed with autism (HL-ASD; n = 31) and two non-autistic control groups: HL-Neg (HL infants not diagnosed with autism; n = 126) and LL-Neg (typically developing infants who did not have an older sibling with autism; n = 77). Using a whole-brain approach, we measured cortical thickness and surface area at 6 and 12 months and expressive and receptive language abilities at 24 months. Partial least squares correlation analyses were computed separately for each of the three groups. Results from the HL-ASD group indicated negative associations between surface area in the left inferior frontal gyrus and 24-month language abilities. Notably, regions outside the standard adult language network were also associated with language in the HL-ASD group. Results in the HL-ASD group highlight the distinct processing guiding development of surface area and cortical thickness; associations were mostly negative for surface area at 6 months but mostly positive for cortical thickness at the same time point. Results from this data-driven study align with the theory of interactive specialization-a theory highlighting the dynamic nature of the infant brain-and advocate for a whole-brain approach in investigating early brain-behavior neurodevelopment in ASD.

Indexed as

Autism Spectrum DisorderCerebral CortexLanguage DevelopmentChild, PreschoolFemaleHumansInfantMagnetic Resonance ImagingMaleSiblingsautismcortical thicknessinfantslanguagesurface area

Identifiers

PMID40348602
PMCPMC12063482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.