Evidence map›Paper›PMID 40348296›Full record

ArticleMagnetic resonance imaging2025

Advancement of an automatic segmentation pipeline for metallic artifact removal in post-surgical ACL MRI.

Dominique A Barnes, Crystal J Murray, Janine Molino, Jillian E Beveridge, Ata M Kiapour, Martha M Murray, Braden C Fleming

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Dominique A BarnesDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, RI, USA; Rhode Island Hospital, Providence, RI, USA; Institute for Biology, Engineering, and Medicine, Brown University, Providence, RI, USA.
Crystal J MurrayDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, RI, USA; Rhode Island Hospital, Providence, RI, USA.
Janine MolinoDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, RI, USA; Brown University Health Biostatistics, Epidemiology, Research Design, & Informatics Core, Rhode Island Hospital, Providence, RI, USA.
Jillian E BeveridgeDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, RI, USA; Rhode Island Hospital, Providence, RI, USA; Institute for Biology, Engineering, and Medicine, Brown University, Providence, RI, USA.
Ata M KiapourDepartment of Orthopaedic Surgery and Sports Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Martha M MurrayDepartment of Orthopaedic Surgery and Sports Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Braden C FlemingDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, RI, USA; Rhode Island Hospital, Providence, RI, USA; Institute for Biology, Engineering, and Medicine, Brown University, Providence, RI, USA. Electronic address: Braden_Fleming@brown.edu.

Funding

Pilot Projects ProgramP30GM122732 · NIGMS · RHODE ISLAND HOSPITAL · PI CRISCO, JOSEPH J · 2017 to 2021
$6.6M
Non-invasive Assessment of Ligament Healing, in VivoR01AR065462 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2014 to 2016
$2.1M
The Effects of Reduced ACL Stiffness on Dynamic In Vivo Joint FunctionR00AR069094 · NIAMS · RHODE ISLAND HOSPITAL · PI BEVERIDGE, JILLIAN ELIZABETH · 2019 to 2021
$730k
NIAMS NIH HHS R00 AR069094NIAMS NIH HHS R01 AR065462NIGMS NIH HHS P30 GM122732
6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) has the potential to identify post-operative risk factors for re-tearing an anterior cruciate ligament (ACL) using a combination of imaging signal intensity (SI) and cross-sectional area measurements of the healing ACL. During surgery micro-debris can result from drilling the osseous tunnels for graft and/or suture insertion. The debris presents a limitation when using post-surgical MRI to assess reinjury risk as it causes rapid magnetic field variations during acquisition, leading to signal loss within a voxel. The present study demonstrates how K-means clustering can refine an automatic segmentation algorithm to remove the lost signal intensity values induced by the artifacts in the image. MRI data were obtained from 82 patients enrolled in three prospective clinical trials of ACL surgery. Constructive Interference in Steady State MRIs were collected at 6 months post-operation. Manual segmentation of the ACL with metallic artifacts removed served as the gold standard. The accuracy of the automatic ACL segmentations was compared using Dice coefficient, sensitivity, and precision. The performance of the automatic segmentation was comparable to manual segmentation (Dice coefficient = .81, precision = .81, sensitivity = .82). The normalized average signal intensity was calculated as 1.06 (±0.25) for the automatic and 1.04 (±0.23) for the manual segmentation, yielding a difference of 2%. These metrics emphasize the automatic segmentation model's ability to precisely capture ACL signal intensity while excluding artifact regions. The automatic artifact segmentation model described here could enhance qMRI's clinical utility by allowing for more accurate and time-efficient segmentations of the ACL.

Indexed as

Anterior Cruciate LigamentAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionArtifactsImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMetalsAdultAlgorithmsFemaleHumansMaleReproducibility of ResultsSensitivity and SpecificityYoung AdultMetalsACLArtifactsMachine LearningMRI

Identifiers

PMID40348296
PMCPMC12136983

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.