Evidence map›Paper›PMID 40347495›Full record

ArticleChembiochem : a European journal of chemical biology2025

Cyanophenylalanine as an Infrared Probe for Iron-Sulfur Cluster Redox State in Multicenter Metalloenzymes.

Zehui Duan, Jiaao Wei, Stephen B Carr, Miguel Ramirez, Rhiannon M Evans, Philip A Ash, Patricia Rodriguez-Macia, Amit Sachdeva, Kylie A Vincent

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Crystallise, poise, capture: a multimodal platform for correlated structural and spectroscopic characterisation of redox enzymes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zehui DuanDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.
Jiaao WeiDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.
Stephen B CarrDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.ORCID https://orcid.org/0000-0002-1473-457X
Miguel RamirezDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.
Rhiannon M EvansDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.
Philip A AshDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.ORCID https://orcid.org/0000-0001-5264-464X
Patricia Rodriguez-MaciaDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.ORCID https://orcid.org/0000-0003-3513-0115
Amit SachdevaSchool of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.ORCID https://orcid.org/0000-0002-3704-5750
Kylie A VincentDepartment of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.ORCID https://orcid.org/0000-0001-6444-9382

Funding

Biotechnology and Biological Sciences Research Council BB/R004692/1Biotechnology and Biological Sciences Research Council BB/R018413/1Biotechnology and Biological Sciences Research Council BB/X002292/1Biotechnology and Biological Sciences Research Council BB/X002624/1European Research Council 819580Wellcome TrustWellcome Trust 204593/Z/16/Z
6 · The paper itself

Abstract

The noncanonical amino acid, para-cyanophenylalanine (CNF), when incorporated into metalloproteins, functions as an infrared spectroscopic probe for the redox state of iron-sulfur clusters, offering a strategy for determining electron occupancy in the electron transport chains of complex metalloenzymes. A redshift of ≈1-2 cm

Indexed as

AlanineHydrogenaseIronIron-Sulfur ProteinsNitrilesCatalytic DomainDesulfovibrio desulfuricansFerredoxinsOxidation-ReductionPhenylalanineSpectrophotometry, InfraredAlanineFerredoxinsHydrogenaseIroniron hydrogenaseIron-Sulfur ProteinsNitrilesp-cyanophenylalaninePhenylalaninecyanophenylalaninehydrogenaseinfrared labelsiron–sulfur clustersspectroelectrochemistry

Identifiers

PMID40347495
PMCPMC12278343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.