Evidence map›Paper›PMID 40347443›Full record

ArticleEpilepsia2025

Anomia prehabilitation in temporal lobe epilepsy surgery: A pilot study.

Véronique Sabadell, Christelle Zielinski, Elodie Garnier, Julia Makhalova, Aileen McGonigal, Stanislas Lagarde, Sandrine Aubert, Nathalie Villeneuve, Henry Dufour, Didier Scavarda and 3 more

Abstract read
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Véronique SabadellAix-Marseille University, INSERM, Institute of Systems Neuroscience, Marseille, France.ORCID https://orcid.org/0000-0002-6707-3023
Christelle ZielinskiAix-Marseille University, CNRS, LPL, Aix-en-Provence, France.
Elodie GarnierAix-Marseille University, INSERM, Institute of Systems Neuroscience, Marseille, France.
Julia MakhalovaAix-Marseille University, INSERM, Institute of Systems Neuroscience, Marseille, France.ORCID https://orcid.org/0000-0001-7962-2942
Aileen McGonigalEpileptology Department, APHM, Timone Hospital, Marseille, France.ORCID https://orcid.org/0000-0001-6775-5318
Stanislas LagardeAix-Marseille University, INSERM, Institute of Systems Neuroscience, Marseille, France.
Sandrine AubertEpileptology Department, APHM, Timone Hospital, Marseille, France.
Nathalie VilleneuveAPHM, Timone Hospital, Pediatric Neuro-Metabolism Unit, Marseille, France.
Henry DufourNeurosurgery Unit, APHM, Timone Hospital, Marseille, France.
Didier ScavardaAix-Marseille University, INSERM, Institute of Systems Neuroscience, Marseille, France.ORCID https://orcid.org/0000-0001-9344-8071
Fabrice BartolomeiAix-Marseille University, INSERM, Institute of Systems Neuroscience, Marseille, France.ORCID https://orcid.org/0000-0002-1678-0297
F-Xavier AlarioAix-Marseille University, CNRS, CRPN, Marseille, France.
Agnès TrébuchonAix-Marseille University, INSERM, Institute of Systems Neuroscience, Marseille, France.

Funding

France 2030 ANR-16-CONV-0002John BostLigue Française Contre l'EpilepsiePHOCEO
6 · The paper itself

Abstract

objectiveAn emerging approach in surgery is to propose prehabilitation programs to strengthen the patient's functional abilities before surgical interventions, thus helping them cope better with its consequences. In drug-resistant language-dominant temporal lobe epilepsy (LdTLE), surgical treatment carries a risk of increasing cognitive deficits, notably word-finding difficulties (anomia) and verbal memory difficulties that negatively impact personal, social, and occupational activities. In this study, we invited 15 LdTLE patients to enroll in a speech and language prehabilitation program adapted to the specifics of their difficulties, organized daily during the preoperative period.

methodsNaming performance (for trained and untrained words) was studied twice before prehabilitation, during prehabilitation, and 1 week and 6 months after surgery. Results were analyzed using a generalized linear mixed effects model.

resultsWe found a significant effect of prehabilitation on trained items before surgery. Postoperatively, trained items showed a slight and nonsignificant performance increase compared to baseline, whereas untrained items showed a significant decline in the same comparison. SIGNIFICANCE: We conclude that trained words were better protected from postsurgical decline than untrained words. Our research can contribute to patient support during surgical decision-making; ultimately, prehabilitation might be considered as part of individualized care. These encouraging results lay the groundwork for more detailed or powerful examinations of the protective effect of prehabilitation on language skills.

Indexed as

AnomiaDrug Resistant EpilepsyEpilepsy, Temporal LobePreoperative CareAdultFemaleHumansMaleMiddle AgedPilot ProjectsPostoperative ComplicationsYoung Adultanomiaepilepsy surgeryleft temporal lobe epilepsyprehabilitationspeech and language therapy

Identifiers

PMID40347443
PMCPMC12455379

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.