Evidence map›Paper›PMID 40347426›Full record

ArticleInternational journal of clinical oncology2025

Impact of lymph-node dissection during radical cystectomy for non-muscle-invasive bladder cancer: Japanese multicenter retrospective study.

Tomokazu Sazuka, Rikiya Taoka, Jun Miki, Ryoichi Saito, Wataru Fukuokaya, Yoshiyuki Matsui, Shingo Hatakeyama, Takashi Kawahara, Ayumu Matsuda, Taketo Kawai and 31 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Development and validation of MRI-based models to predict lymph node metastasis in bladder cancer: a multi-center study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Tomokazu SazukaDepartment of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Rikiya TaokaDepartment of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan. taoka.rikiya@kagawa-u.ac.jp.ORCID http://orcid.org/0000-0003-3243-499X
Jun MikiDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Ryoichi SaitoDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Wataru FukuokayaDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Yoshiyuki MatsuiDepartment of Urology, National Cancer Center Hospital, Tokyo, Japan.
Shingo HatakeyamaDepartment of Urology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Takashi KawaharaDepartment of Urology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Ayumu MatsudaDepartment of Urology, National Cancer Center Hospital, Tokyo, Japan.
Taketo KawaiDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Minoru KatoDepartment of Urology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Takeshi SanoDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Fumihiko UrabeDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Soki KashimaDepartment of Urology, Akita University Graduate School of Medicine, Akita, Japan.
Hirohito NaitoDepartment of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Yoji MurakamiDepartment of Urology, Graduate School of Life Science, Kumamoto University, Kumamoto, Japan.
Makito MiyakeDepartment of Urology, Nara Medical University, Nara, Japan.
Kei DaizumotoDepartment of Urology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Yuto MatsushitaDepartment of Urology, Hamamatsu University School of Medicine, Shizuoka, Japan.
Takuji HayashiDepartment of Urology, Osaka International Cancer Institute, Osaka, Japan.
Junichi InokuchiDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yusuke SuginoDepartment of Nephro-urologic Surgery and Andrology, Mie University Graduate School of Medicine, Mie, Japan.
Kenichiro ShigaDepartment of Urology, Harasanshin General Hospital, Fukuoka, Japan.
Noriya YamaguchiDepartment of Urology, Faculty of Medicine, Tottori University, Tottori, Japan.
Shingo YamamotoDepartment of Urology, Hyogo Medical University, Hyogo, Japan.
Keiji YasueDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Takashige AbeDepartment of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
Shotaro NakanishiDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Ginowan, Japan.
Katsuyoshi HashineDepartment of Urology, National Hospital Organization Shikoku Cancer Center, Ehime, Japan.
Atsuro SawadaDepartment of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kiyoaki NishiharaDepartment of Urology, Kurume University School of Medicine, Fukuoka, Japan.
Hiroaki MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan.
Shuichi TataranoDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Koichiro WadaDepartment of Urology, Faculty of Medicine, Shimane University, Shimane, Japan.
Sho SekitoDepartment of Urology, Aichi Cancer Center Hospital, Aichi, Japan.
Ryo MaruyamaDepartment of Urology, Niigata University Graduate School of Medicine, Niigata, Japan.
Naotaka NishiyamaDepartment of Urology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Hiroyuki NishiyamaDepartment of Urology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Hiroshi KitamuraDepartment of Urology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Tomohiko IchikawaDepartment of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Japan Urological Oncology Group

Funding

Japan Society for the Promotion of Science 22K09494
6 · The paper itself

Abstract

backgroundThere is no definitive consensus on the necessity and impact of lymph-node dissection during radical cystectomy for non-muscle-invasive bladder cancer (NMIBC). This study aimed to evaluate the prognostic significance of lymph-node dissection in NMIBC and identify preoperative factors influencing non-urinary tract recurrence-free survival (NUTRFS).

methodsWe retrospectively analyzed data for 2674 cases of bladder cancer treated with radical cystectomy between January 2013 and December 2019 from a multicenter Japanese database; 410 patients were preoperatively diagnosed with NMIBC. Patients were divided into lymph-node dissection and non-lymph-node dissection groups, and NUTRFS and overall survival were compared as endpoints. Univariate and multivariate analyses were performed to determine NUTRFS prognostic factors.

resultsLymph-node dissection was performed in 374/410 patients and not in 36/410. Compared with the lymph-node dissection group, the non-lymph-node dissection group was older, and had a lower proportion of a performance status of 0 and a higher proportion of clinical stage < T1 disease. The pathological lymph-node positivity rate in the lymph-node dissection group was 6.9%. However, lymph-node dissection did not provide a statistically significant prolonged survival. Results remained consistent after propensity score matching. Multivariate analysis revealed poor performance status and bladder neck tumors as independent risk factors for NUTRFS. Lymph-node dissection was not a significant prognostic factor in preoperatively diagnosed NMIBC.

conclusionsRoutine lymph-node dissection may be unnecessary for all NMIBC cases; however, our findings suggest that this should be considered for NMIBC involving the bladder neck.

Indexed as

CystectomyLymph Node ExcisionUrinary Bladder NeoplasmsAgedAged, 80 and overEast Asian PeopleFemaleHumansJapanLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm InvasivenessNon-Muscle Invasive Bladder NeoplasmsPrognosisLymph-node dissectionNon-muscle-invasive bladder cancerPositivity rateRadical cystectomySurvival

Identifiers

PMID40347426

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