SynthesisTechniques in coloproctology2025
Effects of low anterior resection syndrome after colorectal cancer resections on health-related quality of life: a systematic review and meta-analysis.
Synthesis in Techniques in coloproctology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Tertiary lymphoid structures guided opportunities and challenges for immunotherapy in early gastroesophageal junction cancer and low rectal cancer.Human vaccines & immunotherapeutics · 2026Review
- Histopathological proof-of-concept validation of AI-assisted peripheral neural track recognition during laparoscopic gastrointestinal surgery.Surgical endoscopy · 2026Article
- Incremental Predictive Value of Conventional MRI Pelvimetry for Major Low Anterior Resection Syndrome After Rectal Cancer Surgery.Journal of clinical medicine · 2026Article
- Living with low anterior resection syndrome after rectal cancer surgery: challenges, self-management, and supportive care priorities.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- [Anorectal functional disorders following organ-preserving treatment and resection of rectal cancer].Chirurgie (Heidelberg, Germany) · 2026Review
- Development and validation of web-based prediction models for major low anterior resection syndrome at 3 and 6 months after sphincter-preserving surgery in patients with rectal cancer.International journal of colorectal disease · 2026Article
- Patients' experiences of participating in a nurse-led clinic for bowel dysfunction following rectal cancer: A qualitative interview study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Effectiveness of pelvic floor rehabilitation in the prevention and treatment of postoperative bowel symptoms in patients with rectal cancer: a systematic review and meta-analysis of randomized controlled trials.Journal of cancer survivorship : research and practice · 2026Review
- Trajectories of psychological distress and associated factors in patients with postoperative Low Anterior Resection Syndrome: a longitudinal latent class analysis.Frontiers in psychology · 2026Article
- Ileostoma as a promising tool in pathophysiological study and clinical intervention: a review from bench to beside.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow anterior resection syndrome (LARS) is a term that encompasses multidimensional bowel dysfunction that typically occurs following resections of rectum and distal parts of the colon. We aimed to systematically assess the available literature on the effects of bowel dysfunction after colorectal cancer (CRC) surgeries on health-related quality of life (HRQOL) and conduct a meta-analysis.
methodsStudies were included if they assessed patients who had undergone sphincter-preservation surgeries for CRC. Studies were eligible if they assessed bowel dysfunction using the LARS score and HRQOL using the European Organization for Research and Treatment Core Quality-of-Life Questionnaire (EORTC QLQ-C30).
resultsOf 1410 reports, 28 studies were included. According to the analyses, patients with major LARS had lower global health status [weighted mean differences (WMD) = - 10.98; 95% confidence interval (CI) - 13.18, - 8.79], physical functioning (WMD = - 5.96; 95% CI - 7.40, - 4.52), role functioning (WMD = - 10.59; 95% CI - 12.54, - 8.63), emotional functioning (WMD = - 11.09; 95% CI - 14.34, 7.84), cognitive functioning (WMD = - 9.27; 95% CI - 12.22, - 6.32), and social functioning (WMD = - 15.73; 95% CI - 18.82, - 12.63) and higher scores of symptoms compared to patients with minor/no LARS.
conclusionsThe study findings suggest that patients with major LARS experience worse HRQOL compared to those with minor/no LARS. REGISTRATION: PROSPERO, CRD42023479657.
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