ArticleJournal of assisted reproduction and genetics2025
The effects of GnRH analogues on endometrial receptivity: a comprehensive study.
Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of dual trigger on pregnancy outcomes in women with diminished ovarian reserve: A single-blind randomized clinical trial.International journal of reproductive biomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeEndometrial receptivity is a critical determinant of successful embryo implantation and pregnancy. Gonadotropin-releasing hormone (GnRH) analogues are widely used in in vitro fertilization (IVF) but their effects on endometrial receptivity remain incompletely understood. This study aims to investigate the impact of GnRH analogues on endometrial receptivity through various in vitro models.
methodsEndometrial samples were collected across various stages of the menstrual cycle. The expression of the gonadotropin-releasing hormone receptor (GnRHR) was analyzed and quantified. A 3D endometrial model was constructed, and effects of GnRH analogues on trophoblast adhesion, as well as on the expression of markers related to endometrial receptivity, were assessed.
resultsThe results indicate that GnRHR expression is higher in epithelium in the secretory phase. However, no significant difference in the adhesion of trophoblast cell spheres to endometrial cells across different GnRH analogue concentrations was observed. GnRH analogues did not affect gene mRNAs expressions or protein levels either. Proteomic analysis revealed a downregulation of ITGAE in the antagonist regimen and an upregulation of FAAH2 in the agonist regimen.
conclusionsThis study suggests that GnRH analogues at different physiological concentrations used in IVF protocols do not significantly impact primary markers of endometrial receptivity. However, the use of antagonist may have an adverse effect on endometrial receptivity. Further research is required to elucidate indirect mechanisms by which GnRH analogues might affect endometrial receptivity and IVF outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.