ArticleAnnals of intensive care2025
Impact of substance use disorders on critical care management and health outcomes in septic adolescents.
Article in Annals of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Drug-laced vaping-implications and emerging perioperative challenges for the anesthesiologist: a narrative review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Review
- An Institutional Provider Survey Evaluating Access and Implementation of Opioid Use Disorder Treatment in the Intensive Care Unit.Journal of addiction medicine · 2026Article
- Behavioral and social pathways of adolescent drug use in Indonesia: implications for community-based prevention.BMC public health · 2026Article
- A reassessment of the impact of substance use disorder on outcomes in adolescent sepsis.Annals of intensive care · 2025Article
- The history of substance abuse disorder in critically ill septic adolescent patients is associated with increased utilization of critical care resources and organ dysfunction.Annals of intensive care · 2025Article
- Harnessing artificial intelligence to address substance use disorders in critically ill adolescents: a synergistic approach.Annals of intensive care · 2025Article
- Medications for opioid use disorder receipt in intensive care patients with opioid use disorder-A statewide cohort study.Journal of opioid managementObservational
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Abstract
backgroundAdult septic patients with substance abuse disorder (SUD) are at increased risk of poor outcomes, but the impact on adolescents is unknown. We aimed to determine if pre-existing SUD is associated with increased adverse outcomes and critical care resources in critically ill adolescents hospitalized with sepsis. We hypothesize that SUD is associated with increased risk of adverse outcomes and usage of critical care resources in this adolescent patient population.
methodsThis was a retrospective cohort study utilizing the TriNetX© electronic health record (EHR) database, which consists of EHR from participating healthcare organizations predominantly in the United States. Critically ill adolescents with sepsis aged 12-21 years were divided into two groups (SUD history and no-SUD history). Data related to demographics, diagnostic, procedural, and medication codes were analyzed. The primary outcomes were organ dysfunction, critical care therapies, and all-cause 1-year mortality.
resultsWe included 5,436 critically ill adolescents with sepsis [730 (13.43%) SUD history and 4706 (86.57%) no-SUD history]. SUD history was associated with increased odds of organ dysfunction (adjusted odds ratio [aOR] 1.84; 95% confidence interval [CI] 1.56-2.16; p < 0.001), vasoactive/inotropic drug usage (aOR 1.29; 95% CI 1.10-1.52; p = 0.002), mechanical ventilation (aOR 2.19; 95% CI 1.85-2.59; p < 0.001), but not mortality (aOR 1.03; 95% CI 0.76-1.41; p = 0.83).
conclusionsOur retrospective analysis suggests history of SUD in critically ill septic adolescent patients is associated with increased utilization of critical care resources and organ dysfunction. Further study is needed to determine if substance abuse represents a potentially modifiable risk factor for critical illness in adolescent patients.
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