Evidence map›Paper›PMID 40347302›Full record

ArticleJournal of gastrointestinal cancer2025

The Significance of Screening Endoscopy at 2-Year Interval for Detecting Pharyngeal and Esophageal Cancer in the Japanese General Population.

Kazuhiro Kashiwagi, Toshifumi Yoshida, Satoshi Kinoshita, Hiromasa Nakamizo, Rieko Nakamura, Hiromasa Takaishi, Yasushi Iwao, Takanori Kanai

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Incidental detection of cancers during population-based endoscopic gastric cancer screening in Japan.Esophagus : official journal of the Japan Esophageal Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kazuhiro KashiwagiCenter for Preventive Medicine, Keio University, #7 Azabudai Hills Mori JP Tower, 1-3-1 Azabudai, Minato-Ku, Tokyo, 106-0041, Japan. kashiwagi.z2@keio.jp.
Toshifumi YoshidaCenter for Preventive Medicine, Keio University, #7 Azabudai Hills Mori JP Tower, 1-3-1 Azabudai, Minato-Ku, Tokyo, 106-0041, Japan.
Satoshi KinoshitaCenter for Preventive Medicine, Keio University, #7 Azabudai Hills Mori JP Tower, 1-3-1 Azabudai, Minato-Ku, Tokyo, 106-0041, Japan.
Hiromasa NakamizoCenter for Preventive Medicine, Keio University, #7 Azabudai Hills Mori JP Tower, 1-3-1 Azabudai, Minato-Ku, Tokyo, 106-0041, Japan.
Rieko NakamuraCenter for Preventive Medicine, Keio University, #7 Azabudai Hills Mori JP Tower, 1-3-1 Azabudai, Minato-Ku, Tokyo, 106-0041, Japan.
Hiromasa TakaishiCenter for Preventive Medicine, Keio University, #7 Azabudai Hills Mori JP Tower, 1-3-1 Azabudai, Minato-Ku, Tokyo, 106-0041, Japan.
Yasushi IwaoCenter for Preventive Medicine, Keio University, #7 Azabudai Hills Mori JP Tower, 1-3-1 Azabudai, Minato-Ku, Tokyo, 106-0041, Japan.
Takanori KanaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe previously identified examination time and 2-year interval as effective quality indicators for detecting upper gastrointestinal cancer during screening esophagogastroduodenoscopy (EGD). We evaluated the significance of biennial endoscopy in detecting pharyngeal and esophageal cancer.

methodsIndividuals who underwent multiple EGD examinations as health checkups at our center between August 2012 and January 2022 were included. Endoscopists were categorized into two groups based on their mean examination time for normal EGD findings, using a threshold of 5 min. The associations between cancer detection rate and these indicators were analyzed using multivariable analyses.

resultsTwelve endoscopists performed more than 1000 examinations each, for a total of 28,842 examinations, detecting all (6 pharyngeal and 26 esophageal) cancers. Intervals between endoscopies were classified into three groups: ≤ 1 year (Group 1), 1 to ≤ 2 years (Group 2), and > 2 years (Group 3). This cancer detection rate did not differ significantly between Groups 1 and 2 (p = 0.761) but was significantly higher in Group 3 than in Group 2 (OR = 4.356, 95% CI = 1.161-16.333, p = 0.029). When Groups 1 and 2 were combined (≤ 2 years) and compared with Group 3, an interval of > 2 years was significantly associated with a higher detection rate, including cases not curable by endoscopic resection (OR, 4.710; 95% CI, 1.806-12.282; p = 0.002). Examination time was not associated with the cancer detection rate (p = 0.944).

conclusionsThese findings support the significance of biennial endoscopy in detecting pharyngeal and esophageal cancer as well.

Indexed as

Early Detection of CancerEndoscopy, Digestive SystemEsophageal NeoplasmsMass ScreeningPharyngeal NeoplasmsAgedEast Asian PeopleFemaleHumansJapanMaleMiddle AgedRetrospective StudiesTime FactorsEsophageal cancerEsophagogastroduodenoscopyInterval between endoscopiesObservation timePharyngeal cancerQuality indicator

Identifiers

PMID40347302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.