Evidence map›Paper›PMID 40347250›Full record

ArticleHuman genetics2025

A genomic tale of inbreeding in western Mediterranean human populations.

Candela L Hernández, Luis J Sánchez-Martínez, Francisco C Ceballos, Jean M Dugoujon, Luisa Pereira, Rosario Calderón

Erratum issuedAbstract read
In one paragraph

Article in Human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Candela L HernándezDepartamento de Biodiversidad, Ecología y Evolución, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Madrid, Spain. clhernan@ucm.es.ORCID http://orcid.org/0000-0002-0816-7169
Luis J Sánchez-MartínezDepartamento de Biodiversidad, Ecología y Evolución, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-9700-3608
Francisco C CeballosInstituto de Salud Carlos III, Santiago de Compostela, 15706, Spain.ORCID http://orcid.org/0000-0001-7113-7387
Jean M DugoujonCNRS UMR 5288 Laboratoire d'Anthropologie Moléculaire et d'Imagerie de Synthèse (AMIS), Université Paul Sabatier Toulouse III, Toulouse, France.
Luisa Pereirai3S, Instituto de Investigação e Inovaçãao em Saúde, Universidade do Porto, Porto, Portugal.ORCID http://orcid.org/0000-0002-4271-1527
Rosario CalderónDepartamento de Biodiversidad, Ecología y Evolución, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-9196-5323

Funding

Ministerio de Economía y Competitividad CGL2014-53985-R
6 · The paper itself

Abstract

Consanguineous marriages are common in many worldwide human populations, and the biological consequences for offspring can be relevant at the biomedical level. The current genomic revolution displayed through genome-wide studies is challenging the paradigm in the analysis of consanguinity. Here, we analyzed genomic inbreeding patterns in human populations located at the western edge of the Mediterranean region (Iberia and Morocco). Runs of Homozygosity (ROH) (autozygosity fragments) were identified in 139 autochthonous individuals originating from southern Iberia and Morocco via microarray data. All individuals analyzed carried at least one ROH in their genomes. The genomic inbreeding coefficient (F

Indexed as

ConsanguinityGenetics, PopulationGenome, HumanInbreedingFemaleGenomicsHomozygoteHumansMaleMediterranean RegionMorocco

Identifiers

PMID40347250
PMCPMC12401773

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.