ArticleInternational journal of colorectal disease2025
Drug dissolution problems in ostomy patients: a chart review and patient interview analysis.
Article in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Medication-related challenges in patients living with an ostomy: Insights from a national cross-sectional exploratory survey.Exploratory research in clinical and social pharmacy · 2026Article
- Implementation and Clinical Impact of a Structured Clinical Pharmacy Service for Hospitalized Ileostomy Patients: A Retrospective Observational Study Using the RE-AIM Framework.Pharmacy (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe pharmacokinetic properties of peroral drugs, e.g. considering dissolution, release and absorption, can be influenced by a shortened transit time after ostomy placement. Its aim was to find unexpected undissolved drugs in stoma bags and establish a correlation with formulations using patient interviews and chart review analysis.
methods(i) A patient chart review was performed to assess prescribed drugs on the basis of their formulation and potential influence on pharmacokinetics. (ii) Subsequent to the chart review, the patient was interviewed to ascertain (ii.a) the appearance of indigested drugs in the stoma bag, (ii.b) observed changes in drug efficacy and therapy, and (ii.c) information status regarding indigestible and undissolved formulations.
results(i) 22.4% (134/598) of the prescribed formulations were assessed as critical concerning their pharmacokinetic release characteristics. (ii.a) A total of 22.0% (11/50) of the interviewed patients indicated that they had experienced this at least once. (ii.b) Of the patients, 14.0% (7/50) observed changes in drug efficacy, and 12% (6/50) experienced changes in their therapy regimens. (ii.c) More than 60% of the patients lacked information that indigestible and undissolved formulations could be found in their stoma bag.
conclusionsA considerable proportion of formulations investigated caused problems for patients with ostomy. Additional patient education and resources are needed to support ostomy patients by managing drug release-related problems.
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