Evidence map›Paper›PMID 40347226›Full record

ArticleClinical oral investigations2025

Causal association between female reproductive factors and periodontitis: evidence from Mendelian randomization study.

Yichen Xiong, Binjie Liu, Wenjie Li, Jun Chen

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yichen XiongXiangya School of Stomatology, Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine, Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Changsha, 410000, China.
Binjie LiuXiangya School of Stomatology, Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine, Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Changsha, 410000, China.
Wenjie LiXiangya School of Stomatology, Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine, Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Changsha, 410000, China.
Jun ChenXiangya School of Stomatology, Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine, Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Academician Workstation for Oral-maxillofacial and Regenerative Medicine, Changsha, 410000, China. chenjun1222@csu.edu.cn.

Funding

Graduate Education and Teaching Reform of Central South University 2023JGB051Graduate Education and Teaching Reform of Central South University 2024JGB039Hunan Province Graduate Teaching Reform Research Project 2023JGYB047Natural Science Foundation of Changsha kq2403114Natural Science Foundation of Hunan Province 2024JJ5506New Clinical Practice Technology Project of Xiangya Stomatological Hospital, Central South University 2023JS01New Clinical Practice Technology Project of Xiangya Stomatological Hospital, Central South University 2023JS04
6 · The paper itself

Abstract

objectivesTo evaluate the causal relationship between female reproductive factors and periodontitis, and identify potential mediators underlying these associations. MATERIALS AND

methodsThe genome-wide association study (GWAS) summary statistics from different consortiums was used to search for single nucleotide polymorphisms (SNPs) strongly associated with exposures as instrumental variables (IVs). The causality between female reproductive factors and periodontitis was measured by univariable mendelian randomization (UVMR). The mediation analysis was conducted by two-step mendelian randomization (Two-Step MR). The reverse MR was utilized to examine potential reverse causality.

resultsThe age of menarche (β 0.1328; 95%CI 0.0454-0.2203; p 0.0029) and the age of first birth (β 0.1222; 95%CI 0.171-0.2247; p 0.0227) were positively correlated with chronic periodontitis. And the mediation analysis suggested that the heel bone mineral density (BMD) mediated the correlation between the age of menarche and chronic periodontitis.

conclusionsThe age of menarche and the age of first birth have causal relationships with the infection risk of chronic periodontitis. Further clinical and laboratory researches are needed to clarify the mechanism behind the newly found causality. CLINICAL RELEVANCE: This study suggested that the later the age of menarche and first labor, the higher the susceptibility to chronic periodontitis, which may help the clinicians strengthen the prevention and treatment of periodontitis in women.

Indexed as

Chronic PeriodontitisMenarchePeriodontitisAge FactorsBone DensityCausalityFemaleGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk FactorsFemale reproductive factorsMendelian randomizationPeriodontitis

Identifiers

PMID40347226

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