Evidence map›Paper›PMID 40347223›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2025

Macular retinal function after autologous retinal transplantation in patients with refractory macular holes.

Rei Arasaki, Tatsuya Inoue, Hiroko Terasaki, Shinji Ueno, Kazushige Tsunoda, Jun Takeuchi, Shohei Kitahata, Yasuo Yanagi, Maiko Maruyama-Inoue, Kazuaki Kadonosono

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In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rei ArasakiDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Tatsuya InoueDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan. inouet-tky@umin.ac.jp.ORCID 0000-0002-2481-0222
Hiroko TerasakiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Aichi, Japan. terasaki@med.nagoya-u.ac.jp.
Shinji UenoDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Kazushige TsunodaDivision of Vision Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Jun TakeuchiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Aichi, Japan.
Shohei KitahataDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Yasuo YanagiDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Maiko Maruyama-InoueDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Kazuaki KadonosonoDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate subjective and objective macular retinal function and morphology in eyes after autologous retinal transplantation (ART).

methodsWe conducted the study in three patients with large macular holes (MHs) who underwent ART. The examination modalities included optical coherence tomography (OCT), microperimetry (MP-3), and focal macular electroretinography (FMERG) with 10-degree and 5-degree stimulus spots under infrared camera monitoring centered on the treated MHs after ART.

resultsAll three patients showed improved visual acuity after the ART; MP-3 showed relatively good sensitivity around the fixation point with a dense scotoma at the center of the graft. All MHs were closed with autologous grafts and the size of MHs was decreased. OCT revealed clearly visible ellipsoid zones of the host retina around the grafted retina, however one transplanted eye showed disorganized outer layer of the host retina near the border of graft-host retina. FMERGs with the 10-degree stimulus were recorded successfully in all three treated eyes with more than half of a- and b-wave amplitudes of the fellow eyes. FMERGs with the 5-degree stimulus were recorded successfully in two of the treated and their fellow eyes.

conclusionsThe FMERGs showed well-maintained macular retinal function after ART. The electrophysiologic and anatomic outcomes suggested that the host retina around the transplanted retina may play an important role in the postoperative macular retinal function with the mechanical support by the graft.

Indexed as

Macula LuteaRetinaRetinal PerforationsElectroretinographyHumansTomography, Optical CoherenceTransplantation, AutologousVisual AcuityVisual FieldsVisual Field TestsVitrectomyAutologous retinal transplantationFocal macular ERGMacular holeVisual function

Identifiers

PMID40347223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.