ArticleJournal of menopausal medicine2025
Assessing the Noninferiority of the Spermidine Hyaluronate Complex Relative to 17β-Estradiol Treatment in the Ovariectomized Murine Model of Vulvovaginal Atrophy.
Article in Journal of menopausal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Topical Spermidine Hyaluronate (Spd-HA) in Vulvovaginal Atrophy: A Preliminary Study.Medicina (Kaunas, Lithuania) · 2025Article
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Authors and funding
2 authors.
Funding
Abstract
objectivesVulvovaginal atrophy (VVA) presents significant challenges in postmenopausal women. VVA is typically managed either with hormonal-estrogenic therapy or nonpharmacologically with hyaluronic acid (HA) treatments. This study has investigated an advanced formulation, Ubigel Donna™, consisting of an spermidine hyaluronate (Spd-HA) complex formed by combining spermidine and HA. Initial clinical trials have demonstrated promising outcomes for this formulation.
methodsLocal administrations of Spd-HA gel, HA gel, and 17β-estradiol (E2) gel were evaluated under a pulsatile regimen in ovariectomized Wistar female rats for assessing therapeutic efficacy.
resultsWhile E2 treatment demonstrated robust tissue revitalization through restored endometrial thickness and estrus-like vaginal epithelia, the HA gel yielded contradicting atrophic conditions (metestrus). The Spd-HA gel demonstrated an intermediate mucosal status with enhanced differentiation. All three treatments demonstrated similar regulation of the vaginal pH.
conclusionsThis study reaffirmed the efficacy of the estrogen replacement therapy. More importantly, the Spd-HA approach can be considered as a promising alternative for patients unable to use hormonal treatments. Thus, Ubigel Donna™ can be considered as an enhanced nonpharmacological solution for the widespread burden of postmenopausal VVA.
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