Evidence map›Paper›PMID 40347163›Full record

ArticleJournal of menopausal medicine2025

Ashwagandha and Shatavari Extracts Dose-Dependently Reduce Menopause Symptoms, Vascular Dysfunction, and Bone Resorption in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Study.

Usharani Pingali, Chandrasekhar Nutalapati, Yan Wang

Abstract read
In one paragraph

Article in Journal of menopausal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Efficacy and safety of Shatavari root extract (Frontiers in reproductive health · 2025
    Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. SheVari4Food & nutrition research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Usharani PingaliDepartment of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India. ushapingali@yahoo.com.ORCID https://orcid.org/0000-0002-9300-8022
Chandrasekhar NutalapatiDepartment of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.
Yan WangSection of Public and Population Health, Division of Oral and Systemic Health Sciences, School of Dentistry, University of California at Los Angeles, Los Angeles, CA, USA. wangyan@ucla.edu.ORCID https://orcid.org/0000-0002-4822-6514

Funding

Oral microbiome establishment and development of Latinx Children at the US-Mexico borderK01DE032775 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yan Wang · 2023 to 2026
$557k
Natreon, Inc.NIDCR NIH HHS K01 DE032775
6 · The paper itself

Abstract

objectivesIn this study, we investigate the effects of dietary supplementation with standardized aqueous extracts of shatavari (

methodsPostmenopausal women aged 40-55 were enrolled in a double-blind randomized study to receive one of six treatments: placebo, Ar 250 mg/500 mg, Ws 250 mg/500 mg, or 500 mg extract combining Ar 250 mg and Ws 250 mg. Primary outcomes were changes in the menopause-specific quality of life (MENQOL) questionnaire, bone mineral density/bone turnover markers (BTMs), and reflection index (RI) after 24 weeks. Secondary outcomes included changes in serum inflammatory and oxidative stress markers, and evaluation of supplement safety and tolerability.

resultsSupplemented groups showed significant dose-dependent decrease MENQOL and RI compared with placebo (

conclusionsDaily supplementation with Ws or Ar extracts dose-dependently reduces menopausal symptoms, vascular dysfunction, bone turnover/resorption, and estrogen deficiency-related inflammation and oxidative stress in postmenopausal women.

Indexed as

Bone densityInflammationOxidative stressPostmenopauseQuality of life

Identifiers

PMID40347163
PMCPMC12070120

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.