ArticleACS applied materials & interfaces2025
Tailoring Cell Behavior and Antibacterial Properties on Zirconia Biomaterials through Femtosecond Laser-Induced Micropatterns and Nanotopography.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Cellular Responses at the Zirconia Dental Implant Interface: A Comprehensive Review.Journal of functional biomaterials · 2026Review
- Time-sequentially released bilayer sandwich cerium oxide nanoparticles on femtosecond laser-treated zirconia implant surface for enhanced antibacterial and osseointegration capacity.Materials today. Bio · 2026Article
- Multiscale hierarchical surface structuring of zirconia using femtosecond laser and chemical etching: implications for cell response and antibacterial performance.Materials today. Bio · 2026Article
- Effects of Laser Applications on Fibroblasts Cultured on Zirconia Surfaces-A Systematic Review.Journal of clinical medicine · 2025Review
- Cellular Responses to Nanoscale Topography Mediated Through the RhoA/ROCK Pathway.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explores the potential of ultrashort pulsed-direct laser interference patterning (USP-DLIP) to fabricate micropatterns on zirconia surfaces, aimed at enhancing their cell-instructive and antibacterial properties for biomedical applications. A femtosecond laser was employed to fabricate 3 and 10 μm periodic linear (L3 and L10) and grid (G3 and G10) patterns on tetragonal zirconia polycrystal stabilized with 3% molar yttrium oxide (3Y-TZP). The patterns exhibited homogeneous, high-aspect-ratio structures with laser-induced nanotopography within the grooves while maintaining minimal surface damage. All patterns significantly enhanced human mesenchymal stem cell (hMSCs) adhesion, spreading, and migration through topographical guidance and nanotopography-induced cell anchoring. Pattern geometry influenced cell morphology and migration: linear patterns induced high elongation and alignment along the grooves, leading to unidirectional migration, while grid structures promoted widespread cells with bidirectional alignment, promoting bidirectional migration. Antibacterial assessment using
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Registered trials
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