Evidence map›Paper›PMID 40347126›Full record

ArticleBrain tumor research and treatment2025

Treatment Outcomes and Prognostic Factors of Intracranial Germ Cell Tumors: A Single Institution Retrospective Study.

Eunjong Lee, Kihwan Hwang, Kyeong-O Go, Jung Ho Han, Hyoung Soo Choi, Yu Jung Kim, Byung Se Choi, In Ah Kim, Gheeyoung Choe, Chae-Yong Kim

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Article in Brain tumor research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Eunjong LeeDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0009-0009-5905-8737
Kihwan HwangDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7211-729X
Kyeong-O GoDepartment of Neurosurgery, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea.ORCID https://orcid.org/0000-0003-3515-3771
Jung Ho HanDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1748-6898
Hyoung Soo ChoiDepartment of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4837-164X
Yu Jung KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5037-0523
Byung Se ChoiDepartment of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6310-1798
In Ah KimDepartment of Radiation Oncology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-9838-5399
Gheeyoung ChoeDepartment of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6547-5603
Chae-Yong KimDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea. chaeyong@snu.ac.kr.ORCID https://orcid.org/0000-0001-9773-5553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study analyzed the epidemiology and treatment outcomes of germ cell tumor patients at a single institution.

methodsA retrospective analysis was conducted on intracranial germ cell tumor (iGCT) patients treated at a single tertiary hospital from 2004 to 2019. Patients were categorized based on treatment modality: Korean Society for Pediatric Neuro-Oncology (KSPNO) protocol or bleomycin, etoposide, and cisplatin with radiation therapy.

resultsForty-nine iGCT patients treated with combined chemotherapy and radiotherapy were analyzed. The median age was 19 years (range: 6-40), with a median follow-up duration of 148.0 months (range: 10.5-265.5). Tumors were most common in the pineal gland (51.0%). Although no significant differences in outcomes were observed between treatment modalities, outcomes varied significantly by pathological type. The 10-year progression-free survival rates for germinoma and non-germinomatous germ cell tumors (NGGCTs) were 88.1% and 32.7%, respectively (

conclusionPure germinoma demonstrated higher survival and lower recurrence rates compared to NGGCT. The KSPNO protocol appears to be an acceptable and safe treatment option for iGCT patients. Further multi-institutional studies with larger cohorts are warranted.

Indexed as

ChemotherapyGerm cell tumorGerminomaOutcomesRadiotherapy

Identifiers

PMID40347126
PMCPMC12070076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.