Evidence map›Paper›PMID 40347073›Full record

ArticleCancer medicine2025

Global Burden of Lip and Oral Cavity Cancer From 1990 to 2021 and Projection to 2040: Findings From the 2021 Global Burden of Disease Study.

Mingxing Chen, Jiangxi Li, Wei Su, Junming Huang, Chuanzhen Yang, Rui Li, Gang Chen

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Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Mingxing ChenMedical Research Public Service Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Beijing, China.
Jiangxi LiMedical Research Public Service Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Beijing, China.
Wei SuSchool of Life Science, Jiangxi Science &Technology Normal University, Nanchang, China.
Junming HuangThe Orthopedic Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Chuanzhen YangMedical Research Public Service Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Beijing, China.
Rui LiNHC Key Laboratory of Systems Biology of Pathogens, State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Gang ChenState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.ORCID https://orcid.org/0009-0000-8814-863X

Funding

China Postdoctoral Science Foundation 2023M741520National Natural Science Foundation of China 61973127National Natural Science Foundation of China 82300994Natural Science Fundation of Jiangxi Province 20232BAB216034Science and Technology Planning Project of Guangdong Province 2017B090901064the Young Research and Cultivation Fund of the First Affiliated Hospital of Nanchang University YFYPY202420
6 · The paper itself

Abstract

backgroundThe aim of this study was to estimate the global burden of lip and oral cavity cancer (LOC) and its trends in different genders, age groups, regions, and countries globally.

methodsData were sourced from the Global Burden of Disease 2021 study.

resultsDuring the 32-year period, a 92.92% and 113.94% increase was estimated in the absolute counts of LOC deaths and disability-adjusted life years (DALYs), respectively. Throughout the 32-year period, males exhibited higher age-standardized rates (ASRs) of incidence (ASIRs), prevalence (ASPRs), mortality (ASMRs), and DALYs (ASDRs) related to LOC. The age group of 60-64 years consistently recorded the highest numbers of new and prevalent cases across the years 1990, 2019, and 2021. In 2019 and 2021, the highest ASMR and ASDR were observed in individuals aged 95 years and older. Regions with low-middle and low socio-demographic index (SDI) consistently showed higher ASMRs and ASDRs associated with LOC from 1990 to 2021. Eastern Europe, South, North, and Southeast Asia exhibited a concentration of countries with higher ASIRs, ASPRs, ASMRs, and ASDRs in 2021. South Asia maintained high levels of ASIRs, ASPRs, ASMRs, and ASDRs in 2021. In 2021, Palau recorded the highest ASIR, ASPR, ASMR, and ASDR, followed by Pakistan. Projections indicate that ASIR, ASPR, ASMR, and ASDR are expected to increase by 7.40%, 10.10%, 2.85%, and 4.60%, respectively, from 2021 to 2040.

conclusionLOC remains a critical public health concern that requires immediate attention, particularly among certain demographics such as males, aged 60-64 or 95 and older, as well as in low- and middle-SDI regions, particularly Eastern Europe, South Asia (notably Pakistan), North Asia, and Southeast Asia.

Indexed as

Global Burden of DiseaseLip NeoplasmsMouth NeoplasmsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolDisability-Adjusted Life YearsFemaleGlobal HealthHumansIncidenceMaleMiddle Agedepidemiologyglobal disease burdenlip and oral cavity cancerspatiotemporal trends

Identifiers

PMID40347073
PMCPMC12065076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.