Evidence map›Paper›PMID 40346971›Full record

ArticleElectrophoresis2025

Electrohydrodynamic Vortex Imaging: A New Tool for Understanding Mass Transfer in Surface-Based Biosensors.

Pauline Zimmer, Oleh Andreiev, Marion Costella, Emmanuelle Laurenceau, Jean-François Bryche, Jean-Pierre Cloarec, Michael Canva, Marie Frénéa-Robin, Julien Marchalot

Abstract read
In one paragraph

Article in Electrophoresis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pauline ZimmerEcole Centrale de Lyon, INSA Lyon, CNRS, Université Claude Bernard Lyon 1, CPE Lyon, INL, UMR5270, Ecully, France.
Oleh AndreievEcole Centrale de Lyon, INSA Lyon, CNRS, Université Claude Bernard Lyon 1, CPE Lyon, INL, UMR5270, Ecully, France.
Marion CostellaEcole Centrale de Lyon, Université Claude Bernard Lyon 1, INSA Lyon, CNRS, Ampère UMR5005, Ecully, France.
Emmanuelle LaurenceauEcole Centrale de Lyon, INSA Lyon, CNRS, Université Claude Bernard Lyon 1, CPE Lyon, INL, UMR5270, Ecully, France.
Jean-François BrycheLaboratoire Nanotechnologies Nanosystèmes (LN2) -IRL3463, CNRS, Université de Sherbrooke, INSA Lyon, École Centrale de Lyon, Université Grenoble Alpes, Sherbrooke, Québec, Canada.
Jean-Pierre CloarecEcole Centrale de Lyon, INSA Lyon, CNRS, Université Claude Bernard Lyon 1, CPE Lyon, INL, UMR5270, Ecully, France.
Michael CanvaLaboratoire Nanotechnologies Nanosystèmes (LN2) -IRL3463, CNRS, Université de Sherbrooke, INSA Lyon, École Centrale de Lyon, Université Grenoble Alpes, Sherbrooke, Québec, Canada.
Marie Frénéa-RobinEcole Centrale de Lyon, Université Claude Bernard Lyon 1, INSA Lyon, CNRS, Ampère UMR5005, Ecully, France.
Julien MarchalotEcole Centrale de Lyon, Université Claude Bernard Lyon 1, INSA Lyon, CNRS, Ampère UMR5005, Ecully, France.

Funding

OBOPHICS ANR-22-CE04-0015Université Grenoble Alpes
6 · The paper itself

Abstract

Surface-based biosensor performance is generally limited by mass transfer, especially when detecting low-concentrated species. To address this, dielectrophoresis (DEP) and alternating current electroosmosis (ACEO) can be combined to enhance mass transfer, increasing the target concentration near the sensor. This article presents a method for real-time direct imaging of electrohydrodynamic (EHD) effects on a microparticle suspension within a microfluidic chamber enclosed by two opposing electrodes. This top-bottom configuration was poorly studied in the literature for ACEO. The system presented thereby allows measurements of fluid flow profiles perpendicular to the electrode surface. The velocity of fluorescent latex microsphere tracers was measured as a function of signal frequency, potential, and electrolyte conductivity. This setup enables direct observation of vortices and particle-depleted areas, offering a valuable tool for selecting optimal input parameters-such as electric field, conductivity, and electrode dimensions-to efficiently concentrate microparticles near the sensor. Additionally, a numerical model developed in COMSOL and adapted for this top-bottom configuration enhances understanding of key parameters influencing EHD phenomena.

Indexed as

Biosensing TechniquesElectroosmosisElectrophoresisMicrofluidic Analytical TechniquesEquipment DesignHydrodynamicsMicrospheresalternating current electroosmosis | dielectrophoresis | surface‐based biosensors | top‐bottom electrodes | vortices

Identifiers

PMID40346971
PMCPMC12514429

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.