ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Filamented Light (FLight) Biofabrication of Aligned Fibrillar Structures to Direct 3D Cell Organization Within Microgels.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Nuclear mechanotransduction: tools for mechanical perturbation and chromatin characterization.Nucleus (Austin, Tex.) · 2026Review
- Shear-Induced Anisotropic Supramolecular Gel Noodles for Improved Cell Guidance in Polarized Tissue Engineering.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Unconventional bioprinting modalities for advanced tissue biofabrication.Biomaterials · 2026Review
- Acoustic Bioprinting: A Glimpse Into an Emerging Field.Small methods · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Controlling cellular organization in hydrogels is of great interest in tissue engineering and regenerative medicine. In the body, cell organization is regulated by aligned extracellular matrices, such as collagen fibers. However, generating patterned extracellular matrix fibers in hydrogels, such as microfabricated gels, is not easily accomplished. Here, filamented-light (FLight)-based 3D microfabrication is used to fabricate microgels with precise internal architecture to direct cellular organization. It is demonstrated that fibrillated rod-shaped microgels encapsulating C2C12 muscle cells promote highly aligned myotube formation, offering potential as mini-injectable muscle tissues for minimally invasive muscle loss therapies. Furthermore, photoreceptor cells encapsulated in rod-shaped microgels generated structures that mimicked the outer retina. Moreover, these microgels can be used as injectable scaffolds, both in vitro and in vivo, where they facilitate angiogenesis when conjugated with QK peptide. Overall, this technique can be used to generate microgels with precise internal architecture thus providing a potentially significant tool for engineering tissue-like structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.