ArticleCNS neuroscience & therapeutics2025
The Variation of White Matter Connectome After Surgery Revealed Factors Affecting Supplementary Syndrome Recovery Time in Low-Grade Glioma Patients.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Connectome-guided glioma resection: a systematic review of white matter tract preservation and postoperative neurocognition.Neurosurgical review · 2026Pooled it
- Awake Craniotomy for Eloquent Region Glioblastoma Classified by Tumor Location-A Retrospective and Prospective Cohort Study.CNS neuroscience & therapeutics · 2026Trial
- Functional gradient analysis reveals potential therapeutic mechanisms of nrTMS for postoperative motor deficits in glioma patients: A randomized controlled trial.NeuroImage. Clinical · 2026Trial
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10 authors.
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Abstract
objectiveSupplementary motor area (SMA) syndrome is a common complication after SMA glioma resection. The compensatory mechanism of the structural sensorimotor network (SMN) and the factors influencing the recovery time of SMA syndrome have not been investigated.
methodsPre- and postoperative diffusion tensor images of 42 low-grade glioma patients with SMA syndrome were processed to construct white matter connectomes. Patients were classified into fast and slow-recovery groups according to whether postoperative motor disorder recovers within 7 days. Fiber counts between nodes and graph theory topological properties were calculated. The shortest distance from the surgical region to the corticospinal tract (d
resultsDecrease of fiber number between lesioned-hemispheric A4ul and contralateral SMN is correlated with prolongation of recovery time. Compared with the slow-recovery group, a higher increase of nodal degree centrality and nodal efficiency of ipsilateral A4ul was found in the fast-recovery group (nodal efficiency: left pre-op: 0.182 ± 0.009, left post-op: 0.231 ± 0.008, p < 0.0001; right pre-op: 0.157 ± 0.021, right post-op: 0.195 ± 0.018, p = 0.0011); (nodal degree centrality: left pre-op: 1.985 ± 0.166; left post-op: 3.195 ± 0.230, p < 0.0001; right pre-op: 1.620 ± 0.389; right post-op: 2.411 ± 0.452, p = 0.0005). Multivariate Cox analysis indicated that the increase in nodal efficiency of A4ul and d
conclusionsThis study revealed an increase in lesioned-hemispheric A4ul nodal efficiency and long d
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